Evidence map›Paper›PMID 40261274›Full record

ArticleeLife2025

Auditory cortex learns to discriminate audiovisual cues through selective multisensory enhancement.

Song Chang, Beilin Zheng, Les Keniston, Jinghong Xu, Liping Yu

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Song ChangKey Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Sciences, East China Normal University, Shanghai, China.
Beilin ZhengCollege of Information Engineering, Hangzhou Vocational and Technical College, Hangzhou, China.
Les KenistonDepartment of Biomedical Sciences, Kentucky College of Osteopathic Medicine, University of Pikeville, Pikeville, United States.
Jinghong XuKey Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Sciences, East China Normal University, Shanghai, China.ORCID https://orcid.org/0000-0002-2864-4196
Liping YuKey Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Sciences, East China Normal University, Shanghai, China.ORCID https://orcid.org/0000-0002-9771-5971

Funding

Natural Science Foundation of China 31970925Natural Science Foundation of China 32271057Natural Science Foundation of China 32371046STI2030-major projects 2021ZD0202600
6 · The paper itself

Abstract

Multisensory object discrimination is essential in everyday life, yet the neural mechanisms underlying this process remain unclear. In this study, we trained rats to perform a two-alternative forced-choice task using both auditory and visual cues. Our findings reveal that multisensory perceptual learning actively engages auditory cortex (AC) neurons in both visual and audiovisual processing. Importantly, many audiovisual neurons in the AC exhibited experience-dependent associations between their visual and auditory preferences, displaying a unique integration model. This model employed selective multisensory enhancement for the auditory-visual pairing guiding the contralateral choice, which correlated with improved multisensory discrimination. Furthermore, AC neurons effectively distinguished whether a preferred auditory stimulus was paired with its associated visual stimulus using this distinct integrative mechanism. Our results highlight the capability of sensory cortices to develop sophisticated integrative strategies, adapting to task demands to enhance multisensory discrimination abilities.

Indexed as

Auditory CortexAuditory PerceptionLearningVisual PerceptionAcoustic StimulationAnimalsCuesMaleNeuronsPhotic StimulationRatsauditory cortexcortical plasticitydecision makingmultisensory integrationneurosciencerat

Identifiers

PMID40261274
PMCPMC12014134

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.