Evidence map›Paper›PMID 40261079›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

Exploring the Modulation of the Complex Folding Landscape of Human Telomeric DNA by a Low Molecular Weight Ligand.

Ines Burkhart, Julia Wirmer-Bartoschek, Janez Plavec, Harald Schwalbe

Abstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ines BurkhartInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe University, Max von Laue Str. 7, 60438, Frankfurt am Main, Germany.
Julia Wirmer-BartoschekInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe University, Max von Laue Str. 7, 60438, Frankfurt am Main, Germany.
Janez PlavecSlovenian NMR Centre, National Institute of Chemistry, Ljubljana, SI-1000, Slovenia.
Harald SchwalbeInstitute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe University, Max von Laue Str. 7, 60438, Frankfurt am Main, Germany.

Funding

Deutsche Forschungsgemeinschaft 531012774Hessisches Ministerium für Wissenschaft und Kunst BMRZ
6 · The paper itself

Abstract

Telomeric DNA forms G-quadruplex (G4) structures. These G4 structures are crucial for genomic stability and therapeutic targeting. Using time-resolved NMR and CD spectroscopy, we investigated how the ligand Phen-DC

Indexed as

DNATelomereCircular DichroismG-QuadruplexesHumansKineticsLigandsMolecular WeightNucleic Acid ConformationPotassiumDNALigandsPotassiumDNA folding kineticsDNA ligand interactionDNA structuresG‐quadruplexesNMR spectroscopy

Identifiers

PMID40261079
PMCPMC12144896

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.