Evidence map›Paper›PMID 40261024›Full record

ArticleApplied and environmental microbiology2025

Identification of a critical gene involved in the biosynthesis of the polyene macrolide lavencidin in

Ryo Otsuka, Yu Sato, Kenji Okano, Eiji Okamura, Hiroya Tomita, Kohsuke Honda, Shigeru Kitani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Draft genome sequence ofMicrobiology resource announcements · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryo OtsukaInternational Center for Biotechnology, Osaka University, Suita, Osaka, Japan.
Yu SatoResearch Center for Thermotolerant Microbial Resources, Yamaguchi University, Yamaguchi, Japan.ORCID 0000-0003-4538-4303
Kenji OkanoDepartment of Life Science and Biotechnology, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan.
Eiji OkamuraDepartment of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Kanagawa, Japan.
Hiroya TomitaInternational Center for Biotechnology, Osaka University, Suita, Osaka, Japan.ORCID 0000-0001-7967-921X
Kohsuke HondaInternational Center for Biotechnology, Osaka University, Suita, Osaka, Japan.ORCID 0000-0001-9069-7574
Shigeru KitaniInternational Center for Biotechnology, Osaka University, Suita, Osaka, Japan.ORCID 0000-0003-2583-6798

Funding

Japan Science and Technology Agency JPMJSP2138Japan Society for the Promotion of Science JP24K01670, JP21K19081Noda Institute for Scientific Research
6 · The paper itself

Abstract

Polyene macrolide antibiotics, produced mainly as secondary metabolites of streptomycetes, have distinct chemical structures and include clinically important antifungal drugs. We recently isolated the 28-membered polyene macrolide lavencidin from

Indexed as

Bacterial ProteinsMacrolidesPolyenesStreptomycesBiosynthetic PathwaysGene EditingMultigene FamilyPolyketide SynthasesBacterial ProteinsMacrolidesPolyenesPolyketide Synthasesbase editinglavencidinpolyene macrolide antibioticsStreptomycestarget-AID

Identifiers

PMID40261024
PMCPMC12093942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.