ArticleChemSusChem2025
Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients.
Article in ChemSusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Mechanochemical Amidation Mediated by 1,1'-Oxalyldiimidazole for the Synthesis of Agrochemicals.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Safe and Sustainable by Design (SSbD) Synthesis of Food and Personal Care Ingredients by Mechanochemistry.ChemSusChem · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Three different reaction types are extensively studied at multi-gram scale by resonant acoustic mixing (RAM): 1) the Knoevenagel condensation to vanillin barbiturate; 2) the Biginelli multicomponent reaction to dihydropyrimidinones, which includes the anticancer drug (±)-Monastrol; and 3) the Biltz synthesis to the antiepileptic drug Phenytoin. The RAM approach demonstrated advantages over traditional solution-based methods by enhancing sustainability and minimizing solvent usage. The processes are assessed by green chemistry metrics and tools (e.g., Chem21 and DOZN 3.0) demonstrating that RAM technology is outperforming compared to the corresponding solution-based methods, representing an environmentally friendly alternative to conventional approaches in organic synthesis and for the preparation of pharmaceuticals in a more sustainable way. The use of milling beads, for grinding-assisted RAM (GA-RAM) processes, alone or in combination with liquid-assisted RAM (LA-RAM), is also investigated, to enhance reaction efficiency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.