Evidence map›Paper›PMID 40260908›Full record

ArticleProtein science : a publication of the Protein Society2025

The LptC transmembrane helix undergoes a rigid body movement upon LptB

Nicholas P Cina, Candice S Klug

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. The LptC transmembrane helix undergoes a rigid body movement upon LptBProtein science : a publication of the Protein Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nicholas P CinaDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Candice S KlugDepartment of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.ORCID 0000-0003-4547-320X

Funding

Lpt protein-mediated transport of LPSR01GM108817 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2014 to 2022
$2.6M
Functional dynamics of essential bacterial proteins and EPR technology developmentR35GM158260 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI CANDICE S KLUG · 2025 to 2026
$935k
An Automated Microscale Thermophoresis Instrument for Southeastern Wisconsin: a Shared Resource for Biomolecular Interactions and Drug DiscoveryS10OD025036 · OD · MEDICAL COLLEGE OF WISCONSIN · PI HILL, R BLAKE · 2019 to 2019
$582k
Upgrades to a Bruker Q-band E580 Pulse EPR SpectrometerS10OD025260 · OD · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2019 to 2019
$478k
Acquisition of Q-band Pulsed EPR CapabilityS10OD011937 · OD · MEDICAL COLLEGE OF WISCONSIN · PI KLUG, CANDICE S · 2012 to 2012
$381k
NIGMS NIH HHS R01 GM108817NIGMS NIH HHS R35 GM158260NIH HHS GM108817NIH HHS OD011937NIH HHS OD025036NIH HHS OD025260NIH HHS S10 OD011937NIH HHS S10 OD025036NIH HHS S10 OD025260
6 · The paper itself

Abstract

Lipopolysaccharide (LPS) is an essential component of the cellular envelope of Gram-negative bacteria and contributes to antibiotic resistance and pathogenesis. Proper localization of LPS at the outer membrane is facilitated via seven distinct LPS transport (Lpt) proteins that bridge the inner and outer membranes. Mature LPS diffuses into the membrane cavity of the inner membrane ABC transporter LptB

Indexed as

ATP-Binding Cassette TransportersEscherichia coliEscherichia coli ProteinsLipopolysaccharidesMembrane ProteinsModels, MolecularProtein Conformation, alpha-HelicalATP-Binding Cassette TransportersEscherichia coli ProteinsLipopolysaccharidesLptC protein, E coliMembrane ProteinsABC transporterDEER spectroscopyEPR spectroscopyGram‐negative bacterialipopolysaccharide transportLptB2FGLptCprotein conformationproteoliposomes

Identifiers

PMID40260908
PMCPMC12012751

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.