ArticleACS applied bio materials2025
Ferritin Fused with MiniSOG for
Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
To avoid off-target effects, targeted cancer therapy offers a feasible alternative to traditional cancer therapies such as chemotherapy and radiotherapy. The human ferritin receptor (transferrin receptor, TfR1) is greatly overexpressed in several cancer types, including liver cancer. Therefore, human ferritin (HFn) has been used in drug encapsulation for targeted therapy. However, the drug encapsulation method is time-consuming and not applicable to all conditions. In this study, we effectively designed HFn fused with a photosensitizing protein called mini-singlet oxygen generator (miniSOG) to create HFn-miniSOG for targeted photodynamic therapy (PDT) applications. The fusion protein HFn-miniSOG self-assembled to form nanoparticles with an average size of 22.4 ± 1.3 nm and generated singlet oxygen (
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