ReviewInternational journal of laboratory hematology2026
Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions.
Review in International journal of laboratory hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- When Fixed-Dose Anticoagulation Meets Frailty.Journal of the American Geriatrics Society · 2026Article
- Measuring Direct Oral Anticoagulant (DOAC) Levels: Applications, Limitations, and Future Directions.International journal of laboratory hematology · 2026Review
- Impact of ileostomy creation on apixaban plasma concentrations: a retrospective case-series.Annals of Saudi medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThere are important challenges with the measurement and interpretation of direct oral anticoagulant (DOAC) anticoagulant effect including a lack of therapeutic ranges, inaccuracy of routinely available coagulation assays, lack of established thresholds for clinically significant effect, and uncertainty about how to apply the results to patient care.
objectiveIn this narrative review, we provide a practical approach to DOAC measurement in clinical practice.
methodsBy summarizing the literature and using illustrative cases, we highlight key principles of commonly available tests, outline potential indications for measuring DOAC drug levels, and provide guidance on interpreting results to inform management decisions.
conclusionWhile DOACs do not require routine monitoring of anticoagulant effect, assessment of plasma DOAC concentration may be helpful in select emergency and non-emergency clinical scenarios.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.