Evidence map›Paper›PMID 40260558›Full record

ArticleMuscle & nerve2025

Incomplete Presentations in Typical Chronic Inflammatory Demyelinating Polyneuropathy: A Single-Center, Retrospective Study.

Young Gi Min, Irad Ahmed, Christina Englezou, Yusuf A Rajabally

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Article in Muscle & nerve, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Young Gi MinDepartment of Translational Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0003-0930-5997
Irad AhmedInflammatory Neuropathy Clinic, Department of Neurology, University Hospitals Birmingham, Birmingham, UK.
Christina EnglezouInflammatory Neuropathy Clinic, Department of Neurology, University Hospitals Birmingham, Birmingham, UK.
Yusuf A RajaballyInflammatory Neuropathy Clinic, Department of Neurology, University Hospitals Birmingham, Birmingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

INTRODUCTION/

aimsIncomplete forms of typical chronic inflammatory demyelinating polyneuropathy (CIDP) have recently been described, but their frequency and clinical characteristics are uncertain. This study aimed to describe a cohort of patients with incomplete typical CIDP.

methodsWe retrospectively analyzed 64 consecutive treatment-naïve patients with CIDP. Phenotypes were classified based on detailed motor examinations, and clinical, electrophysiological, and therapeutic characteristics were compared.

resultsNineteen (30%) subjects with typical CIDP presented with an incomplete phenotype; 12 (63.2%) exhibited a proximal arm-sparing pattern, 3 (15.8%) a distal arm-sparing pattern, 3 (15.8%) a pure paraparetic form, and 1 (5.2%) had a pure proximal form. In cases without full motor recovery, 11 (68.8%) maintained their original phenotype, while the rest transitioned to the complete (18.8%) or to another incomplete form (12.5%) due to involvement of previously unaffected segments. Subjects with incomplete typical CIDP had milder pre-treatment disability and weakness compared to those with the complete form, while other clinical and electrodiagnostic features were comparable. As opposed to the complete form, disability in incomplete typical CIDP at diagnosis showed no correlation with muscle strength. DISCUSSION: Incomplete forms were observed in nearly one-third of subjects with typical CIDP. Incomplete typical CIDP represents a milder form of complete typical CIDP; however, its other disease characteristics, including treatment response, are similar, highlighting the importance of its proper prompt recognition as CIDP. Impairments beyond motor weakness, such as more diffuse proprioceptive loss, might play a role in the disability of patients with incomplete typical forms of CIDP.

Indexed as

Polyradiculoneuropathy, Chronic Inflammatory DemyelinatingAdultAgedElectrodiagnosisElectromyographyFemaleHumansMaleMiddle AgedNeural ConductionRetrospective Studieschronic inflammatory demyelinating polyneuropathycourseincompletephenotyperesponsetreatmenttypical

Identifiers

PMID40260558
PMCPMC12138482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.