Evidence map›Paper›PMID 40260554›Full record

ArticleMacromolecular bioscience2025

Polypept(o)ide-Based Core-Shell Bottlebrush Polymers: A Versatile Platform for Drug Encapsulation.

Bonan Zhao, Jingyuan Wei, Rüdiger Berger, Lin Jian, Kaloian Koynov, Heyang Zhang, Matthias Barz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bonan ZhaoLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.
Jingyuan WeiLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.
Rüdiger BergerPhysics at Interfaces, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Lin JianPhysics at Interfaces, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Kaloian KoynovPhysics at Interfaces, Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
Heyang ZhangLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.
Matthias BarzLeiden Academic Center for Drug Research (LACDR), Leiden University, Einsteinweg 55, Leiden, 2333CC, The Netherlands.ORCID 0000-0002-1749-9034

Funding

Chinese Scholarship CouncilDeutsche Forschungsgemeinschaft SFB1066-3
6 · The paper itself

Abstract

Cylindrical bottlebrush polymers (CBPs) enable the precise adjustment of nanoparticle properties such as size, shape, and functionality exclusively by polymer synthesis. In addition, block copolymer side chains enable direct access to core-shell structure. In this study, the synthesis of polypept(o)ides-based core-shell CBPs is presented through a "grafting-from" strategy. While, poly-lysine (pLys) serves as the backbone, poly(γ-benzyl-l-glutamic acid)-block-polysarcosine (pGlu(OBn)-b-pSar) copolymers form the side chains. This approach enables the synthesis of core-shell nanoparticles, referred as core-shell brushes (CSBs), with hydrodynamic radius (R

Indexed as

Drug CompoundingNanoparticlesPolymersCell Line, TumorHumansPeptidesPolyglutamic AcidPolylysinePeptidesPolyglutamic AcidPolylysinePolymerscore–shell bottlebrush polymersdrug delivery“grafting‐from” synthesispolypept(o)ide

Identifiers

PMID40260554
PMCPMC12259402

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.