Evidence map›Paper›PMID 40260531›Full record

ArticleRenal failure2025

Sodium aescinate protects renal ischemia-reperfusion and pyroptosis through AKT/NLRP3 signaling pathway.

Liu Xin, Ning Kanghao, Li Jiacheng, Yan Xiaodong, Yan Juhan, Zhao Xinyang, Li Xiangdong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liu XinThe First Affiliated Hospital of Hebei North University, Hebei Province, China.
Ning KanghaoGraduate School of Hebei North University, Hebei Province, China.
Li JiachengThe First Affiliated Hospital of Hebei North University, Hebei Province, China.
Yan XiaodongThe First Affiliated Hospital of Hebei North University, Hebei Province, China.
Yan JuhanGraduate School of Hebei North University, Hebei Province, China.
Zhao XinyangThe First Affiliated Hospital of Hebei North University, Hebei Province, China.
Li XiangdongThe First Affiliated Hospital of Hebei North University, Hebei Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal ischemia-reperfusion injury (RIRI) is a common cause of acute renal injury. Studies have shown that sodium aescinate (SA) may serve as a potential therapeutic agent, although its exact mechanism remains unclear. This study first evaluated the efficacy of SA using a mouse renal ischemia-reperfusion model. Subsequently, its mechanism was elucidated through systematic bioinformatics, and finally validated through

Indexed as

Acute Kidney InjuryKidneyNLR Family, Pyrin Domain-Containing 3 ProteinProto-Oncogene Proteins c-aktPyroptosisReperfusion InjuryAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLSignal TransductionNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseProto-Oncogene Proteins c-aktAKT/NLRP3 signalingKidney ischemia-reperfusion injurypyroptosissodium aescinoside

Identifiers

PMID40260531
PMCPMC12016278

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.