ReviewFrontiers in pharmacology2025
Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Curcumin Supplementation Mitigates Oxytetracycline-Induced Hematological, Immunological, and Oxidative Stress in Rainbow Trout (Veterinary sciences · 2026Article
- Neuroprotective Effects of Cistanoside A against Cadmium-induced Neurotoxicity via Keap1/Nrf2/NF-kB Signaling: In Vivo and In Silico approaches.Molecular neurobiology · 2026Article
- Stocking density and dietary inclusion of a multi-component functional feed additive on foot pad dermatitis, welfare indicators, and performance of broiler chickens.Poultry science · 2026Article
- Article
- Curcumin's Protective Effects Against HMolecules (Basel, Switzerland) · 2026Review
- Omega-3-Based Nutraceuticals Suppress LPS-Induced Inflammatory Responses in Primary Human Monocytes.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Targeting mitochondrial dysfunction and neuroprotection in neurodegenerative disorders: emerging therapeutic potential of berberine and polymeric nanoparticle-based delivery systems.Inflammopharmacology · 2026Review
- A Biomimetic Microfluidic Triple-compartment Periodontium-on-chip for Investigation of Inflammatory Responses in Periodontitis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- The Role of Nanocurcumin in Nanoplastics-Induced Pathological Alterations in Largemouth Bass (Antioxidants (Basel, Switzerland) · 2026Article
- Curcumin in Alzheimer's Disease: From Mechanistic Insights to Translational Challenges and Emerging Curcuminoid Strategies.International journal of molecular sciences · 2026Review
- Nature meets immunity: curcumin's role in modulating neutrophil extracellular traps.Inflammopharmacology · 2026Review
- Antioxidant and anti-apoptotic effects of curcumin-loaded nanoliposomes against di-n-butyl phthalate-induced hepatorenal damage in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Curcumin improves bladder dysfunction in diabetic rats by attenuating oxidative stress via the Keap1/NRF2/HO-1 pathway.Translational andrology and urology · 2026Article
- Review
- Curcumin Delivery Systems: From Importance and Microencapsulation Techniques to Molecular Docking and Dynamics for Rational Formulation Design.Topics in current chemistry (Cham) · 2026Review
- Synergistic impacts of garlic and curcumin on growth performance, carcass characteristics, immunity, antioxidant status, and gut histology of broiler chickens.Poultry science · 2026Article
- The Effect of Curcumin Treatment on Healing in a Rat Distal Femoral Osteochondral Defect Model.Cartilage · 2026Article
- Curcumin Attenuates LPS-Induced Migration/EMT and LPS/ATP-Associated IL-1β Release in Androgen-Independent Prostate Cancer Cells.Current issues in molecular biology · 2026Article
- Curcumin ameliorates hepatic insulin resistance by activating PINK1/Parkin-mediated mitophagy.Scientific reports · 2026Article
- The dual roles of natural cannabidiol in combating oxidative stress and inflammation: A potential intestinal guardian.Redox biology · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress refers to an imbalance between oxidative capacity and antioxidant capacity, leading to oxidative damage to proteins, lipids, and DNA, which can result in cell senescence or death. It is closely associated with the occurrence and development of various diseases, including cardiovascular diseases, nephropathy, malignant tumors, neurodegenerative diseases, hypertension, diabetes, and inflammatory diseases. Curcumin is a natural polyphenol compound of β-diketone, which has a wide range of pharmacological activities such as anti-inflammatory, antibacterial, anti-oxidative stress, anti-tumor, anti-fibrosis, and hypolipidemic, demonstrating broad research and development value. It has a wide range of biological targets and can bind to various endogenous biomolecules. Additionally, it maintains the redox balance primarily by scavenging ROS, enhancing the activity of antioxidant enzymes, inhibiting lipid peroxidation, and chelating metal ions. This paper systematically describes the antioxidative stress mechanisms of curcumin from the perspective of signaling pathways, focusing on the Keap1-Nrf2/ARE, NF-κB, NOX, MAPK and other pathways. The study also discusses potential pathway targets and the complex crosstalk among these pathways, aiming to provide insights for further research on curcumin's antioxidant mechanisms and its clinical applications.
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