Evidence map›Paper›PMID 40260276›Full record

ArticleFrontiers in endocrinology2025

Sex differences between atherogenic index of plasma and α-klotho levels in middle-aged and older adults: NHANES 2007-2016.

Cheng Zuo, Zi-Duo Shen, Yaojun Lu

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cheng ZuoDepartment of Cardiology, Central Hospital of Baotou, Baotou, China.
Zi-Duo ShenStroke Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China.
Yaojun LuDepartment of Cardiology, Central Hospital of Baotou, Baotou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Methods: Data were extracted from the National Health and Nutrition Examination Survey 2007-2016 database, and the relationship between AIP and serum α-klotho levels was analyzed using weighted multivariate linear regression. Results: After adjusting for risk factors, AIP showed a significant negative correlation with the logarithm of serum α-klotho levels in women. The trend analysis and smoothed curve fitting showed a nonlinear dose-response relationship. Threshold effect analysis showed a significant difference in the association between AIP and α-klotho before and after the AIP break point (0.434). Subgroup analyses demonstrated that the negative association of AIP with α-klotho was consistent across subgroups. However, the correlation between AIP and serum α-klotho in men was not significant. Discussion: Our study provides new evidence for sex differences in the association between AIP and serum α-klotho levels.

Indexed as

AtherosclerosisGlucuronidaseSex CharacteristicsAgedBiomarkersFemaleHumansKlotho ProteinsMaleMiddle AgedNutrition SurveysRisk FactorsSex FactorsUnited StatesBiomarkersGlucuronidaseKlotho ProteinsKL protein, humanatherogenic index of plasmaklotholipidNHANESsex differences

Identifiers

PMID40260276
PMCPMC12009705

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.