ArticleAfrican journal of thoracic and critical care medicine2025
Computed tomography chest imaging for the detection of pulmonary hypertension in patients with post-tuberculosis lung disease.
Article in African journal of thoracic and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Post-Tuberculosis Lung Disease: Clinicopathologic Insights, Diagnosis, Prevention, and Management.MedComm · 2026Review
- Technical Challenges in Studying Infectious Disease-Associated Pulmonary Hypertension in Low- and Middle-Income Countries with Limited Resources.Infectious disease reports · 2025Review
- Scoping review of post-TB pulmonary vascular disease: Proceedings from the 2nd International Post-Tuberculosis Symposium.Pulmonary circulation · 2024Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Pulmonary hypertension (PH) after tuberculosis is increasingly recognised as important in high-burden tuberculosis settings. However, the ability of computed tomography (CT) imaging to accurately detect PH remains unclear. Objectives: To evaluate the performance of standard CT measurements in detecting PH in patients with post-tuberculosis lung disease (PTLD), and to determine the potential role of CT imaging as a screening tool in this population. Methods: A retrospective study of patients with PTLD was conducted from January 2019 to September 2021. Adult patients with both a CT chest scan and an echocardiogram performed within 9 months of each other were enrolled. A diagnosis of PH by echocardiography was made if the right ventricular systolic pressure (RVSP) was ≥36 mmHg or the peak tricuspid regurgitant jet velocity (TRVmax) >2.8 m/s. Radiological criteria for PH included a pulmonary artery/ascending aorta (PA/AA) diameter ratio >1, pulmonary artery diameter (PAD) ≥29 mm (males) or ≥27 mm (females), and right ventricle/left ventricle (RV/LV) diameter ratio ≥1.28. Spirometry was also performed. Results: Of 173 patients with PTLD, 52 met the inclusion criteria. Significant correlations were found between the CT-measured PA/AA ratio and RVSP (p=0.0083) and TRVmax (p=0.0582), but not between the CT-measured RV/LV ratio and RVSP (p=0.1729) or TRVmax (p=0.0749). PAD was also significantly correlated with RVSP (p=0.0011) and TRVmax (p=0.0023). The PA/AA ratio identified patients with PH on echocardiography with ~100% sensitivity, 65% specificity and a positive predictive value of 39.1%, indicating a high potential for false-positive diagnosis. The forced vital capacity was 13.7% lower in patients with PH than in those without (p=0.044); however, the forced expiratory volume in 1 second was not statistically different. Conclusion: A low PA/AA ratio can be used to rule out the diagnosis of PH in PTLD, but a high PA/AA ratio requires further investigation for PH. Study synopsis:
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