Evidence map›Paper›PMID 40260245›Full record

ArticleFrontiers in immunology2025

Sex-specific impact of B cell-derived IL-10 on tuberculosis resistance.

David Hertz, Sebastian Marwitz, Lars Eggers, Linda von Borstel, Gishnu Harikumar Parvathy, Jochen Behrends, Danny D Jonigk, Rudolf A Manz, Torsten Goldmann, Bianca E Schneider

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David HertzHost Determinants in Lung Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Sebastian MarwitzCore Facility Histology, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Lars EggersHost Determinants in Lung Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Linda von BorstelHost Determinants in Lung Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Gishnu Harikumar ParvathyHost Determinants in Lung Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Jochen BehrendsCore Facility Fluorescence Cytometry, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Danny D JonigkInstitute of Pathology, University Hospital RWTH Aachen, Aachen, Germany.
Rudolf A ManzInstitute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany.
Torsten GoldmannCore Facility Histology, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Bianca E SchneiderHost Determinants in Lung Infections, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Due to the historical dogma that host defense against intracellular pathogens is primarily mediated by cell-mediated immunity, B cells have long been considered unimportant in providing protection against Methods: B cell-specific IL-10 expression was assessed in IL-10 transcriptional reporter (Vert-X) mice following Results: B cells contribute to IL-10 production in the Conclusion: Our research highlights a previously unrecognized sex-specific regulatory role of B cell-derived IL-10 during

Indexed as

B-LymphocytesDisease ResistanceInterleukin-10Mycobacterium tuberculosisTuberculosisAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutSex FactorsIL10 protein, mouseInterleukin-10B cell-derived IL-10HN878mouse modelsex differencestuberculosis

Identifiers

PMID40260245
PMCPMC12009811

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.