Evidence map›Paper›PMID 40260187›Full record

ArticlePatient preference and adherence2025

Perspectives of Healthcare Providers and Patients with Relapsed/Refractory Multiple Myeloma on Treatment Priorities and Novel Therapies.

Sikander Ailawadhi, Yelak Biru, Solène Clavreul, Maite San Miguel, Nicolas Cormier, Yvonne Efebera, Maximilian Merz, Anna Sato, Cathy Zeanah, Jack L Watkins and 3 more

Erratum issuedAbstract read
In one paragraph

Article in Patient preference and adherence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Sikander AilawadhiDivision of Hematology and Medical Oncology, Mayo Clinic, Jacksonville, FL, USA.
Yelak BiruInternational Myeloma Foundation, Studio City, CA, USA.
Solène ClavreulMyeloma Patients Europe, Brussels, Belgium.
Maite San MiguelCancer Center Clínica Universidad de Navarra, Pamplona, Spain.
Nicolas CormierCentre Hospitalier Universitaire de Nantes, Nantes, France.
Yvonne EfeberaOhioHealth, Columbus, OH, USA.
Maximilian MerzMultiple Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Hematology and Cell Therapy, University of Leipzig, Leipzig, Germany.
Anna SatoZS Associates, New York, NY, USA.ORCID 0000-0001-7259-3069
Cathy ZeanahZS Associates, Philadelphia, PA, USA.
Jack L WatkinsPfizer Inc, New York, NY, USA.
James FarrellPfizer Ltd, Dublin, Ireland.
Erinn Hoag GoldmanPfizer Inc, New York, NY, USA.
Rakesh PopatNational Institute for Health Research Clinical Research Facility, University College London Hospitals NHS Trust, London, UK.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Project 4: Targeting Resistance to T-Cell Directed Therapy in Multiple MyelomaP50CA186781 · NCI · MAYO CLINIC ARIZONA · PI Yi Lin · 2015 to 2026
$25.5M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA186781
6 · The paper itself

Abstract

Purpose: With novel therapies including chimeric antigen receptor T-cell (CAR-T) therapy and bispecific antibodies (BsAbs), healthcare providers (HCPs) face complexities managing treatment for patients with relapsed/refractory multiple myeloma (RRMM). This study, among the largest surveys on RRMM, examined unmet needs in care access, barriers to novel therapy use, and treatment decision-making. Methods: This survey-based study (March-June 2024) enrolled 2284 participants (patients: 1301; HCPs: 983) across 7 countries. Patients with >1 relapse/progression and HCPs managing ≥3 patients were included. Data were analyzed using descriptive statistics and Χ Results: For patients, treatment priorities included slowing disease progression (second line [2L], 47%; third or later line [≥3L], 49%), minimizing adverse events (AEs; 2L, 43%; ≥3L, 49%), and extending life (2L, 39%; ≥3L, 38%). HCPs prioritized prolonging survival and controlling disease. Younger patients (<65 vs ≥65 years) prioritized convenience (40% vs 24%; Conclusion: This study revealed gaps in treatment priorities; patients valued quality of life and AE management, while HCPs focused on efficacy and delaying progression. There is a significant need to educate HCPs and patients on the impact of shared decision-making when considering novel treatments for RRMM.

Indexed as

bispecific antibodiesCAR-T therapypatient perspectivessurveys

Identifiers

PMID40260187
PMCPMC12010075

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.