ArticleFrontiers in neurology2025
Evaluation of pressure-induced pain in patients with disorders of consciousness based on functional near infrared spectroscopy.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Research progress on occupational therapy for disorders of consciousness in the context of neurorehabilitation: visual analysis based on CiteSpace.Frontiers in neurologyPooled it
- Towards the use of functional near-infrared spectroscopy as an assessment tool in disorders of consciousness.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to investigate the brain's hemodynamic responses (HRO) and functional connectivity in patients with disorders of consciousness (DoC) in response to acute pressure pain stimulation using near-infrared spectroscopy (NIRS). Methods: Patients diagnosed with DoC underwent pressure stimulation while brain activity was measured using NIRS. Changes in oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) concentrations were monitored across several regions of interest (ROIs), including the primary somatosensory cortex (PSC), primary motor cortex (PMC), dorsolateral prefrontal cortex (dPFC), somatosensory association cortex (SAC), temporal gyrus (TG), and frontopolar area (FPA). Functional connectivity was assessed during pre-stimulation, stimulation, and post-stimulation phases. Results: No significant changes in HbO or HbR concentrations were observed during the stimulation vs. baseline or stimulation vs. post-stimulation comparisons, indicating minimal activation of the targeted brain regions in response to the pressure stimulus. However, functional connectivity between key regions, particularly the PSC, PMC, and dPFC, showed significant enhancement during the stimulation phase ( Conclusion: Although pain-induced brain activation was minimal in patients with DoC, enhanced functional connectivity during pain stimulation suggests that the brain continues to process pain information through coordinated activity between regions. The findings highlight the importance of assessing functional connectivity as a potential method for evaluating pain processing in patients with DoC.
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