ArticleFrontiers in cellular and infection microbiology2025
Alcohol exposure alters the diversity and composition of oral microbiome.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Prevention of HNSCC by chewing gum delivery of enzymes/antimicrobials to reduce carcinogenic acetaldehyde produced by pathogenic microbes.Molecular therapy. Oncology · 2026Article
- Cross-cultural adaptation and psychometric validation of the physical oral health index in Chinese older inpatients.BMC oral health · 2026Article
- Association between the oral microbiota and hyperlipidemia: evidence from a national cross-sectional study.Annals of medicine and surgery (2012) · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
Introduction: Alcohol exposure has been shown to have complex, and sometimes paradoxical, associations with various serious diseases. Currently, there is no knowledge about the effects of alcohol exposure on the dynamics of oral microbial communities. Objective: The study aims to investigate the effects of chronic alcohol consumption on the diversity and composition dynamics of the rat oral microbiota using 16S rRNA gene amplicon sequencing. Methods: In our study, there were 2 groups, including a control group (C group) and an alcohol group (A group), with 10 rats in every group. For ten weeks, rats in the A group were treated with alcohol intragastrically every day, whereas rats in the C group got water. After 10 weeks, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured. Oral swabs were taken from both groups, and total DNA was extracted for high-throughput sequencing of the 16S rRNA gene. Results: According to the results obtained from our study, significant differences were observed in the relative abundances of microbial communities. Alpha diversity measures were statistically significantly higher (P < 0.05) in the A group compared to the C group. At the genus level, alcohol exposure altered the relative abundance of several microbes, including increased relative abundance of Conclusion: Alcohol exposure was associated with the diversity and composition of the oral microbiome. These findings contribute to our understanding of the potential role of oral bacteria in alcohol-related oral and systemic diseases, providing foundational work for future prevention and intervention studies.
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