Evidence map›Paper›PMID 40259895›Full record

ArticleMedical devices (Auckland, N.Z.)2025

Characterization and Optimization of the Subsalve Helmet Ventilation Circuit in a High-Fidelity Acute Respiratory Distress Syndrome (ARDS) Lung Model.

John Donahue, Clinton O Chichester Iii, Alex Hornstein, Michael Lombardi, Amanda M Chichester

Abstract read
In one paragraph

Article in Medical devices (Auckland, N.Z.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John DonahueDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA.ORCID 0009-0009-7192-9099
Clinton O Chichester IiiDepartment of Biomedical and Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA.
Alex HornsteinInventilator LLC, Pawtucket, RI, USA.
Michael LombardiLombardi Undersea LLC, Middletown, RI, USA.
Amanda M ChichesterDepartment of Pharmacy Practice and Clinical Research, University of Rhode Island, Kingston, RI, USA.ORCID 0009-0003-7743-6494

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: The Subsalve helmet continuous positive airway pressure (CPAP) circuit is a low-cost, easy to implement non-invasive ventilation option for treatment of acute respiratory failure. The circuit is simple to set up and operate, and is designed to be used with any commonly available continuous positive airway pressure device. Model Materials and Methods: Simulation of an acute respiratory distress syndrome (ARDS) patient allows optimization of treatment parameters without risk. The boundaries of safe and effective helmet CPAP treatment were measured in the TestChest Results: Moderate CPAP pressure led to significant increases in SpO Conclusion: Our data demonstrate that the Subsalve helmet CPAP circuit, with limited oxygen availability, is an effective treatment strategy for ARDS patients in low-resource settings. Moderate positive end expiratory pressure (PEEP) is recommended to improve blood oxygenation. Subsalve has the potential to conserve critical resources in future epidemics.

Indexed as

acute respiratory distress syndromecontinuous positive airway pressurehelmet-CPAPnoninvasive ventilationpositive end expiratory pressure

Identifiers

PMID40259895
PMCPMC12010036

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.