Evidence map›Paper›PMID 40259788›Full record

ArticleCancer medicine2025

Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine-125 Plaque Radiotherapy Using a Novel Structural-Functional Imaging Analysis System.

Haihan Zhang, Jingyuan Zhu, Yueming Liu, Shiyi Yin, Jinyuan Wang, Yao Yao, Haowen Li, Ximeng Feng, Chuanqing Zhou, Qiushi Ren and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Integrated multimodal assessment of retinal oxygenation, hemodynamics, and neurovisual function in retinal vein occlusion.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haihan ZhangBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jingyuan ZhuBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yueming LiuBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Shiyi YinBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Jinyuan WangBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Yao YaoBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Haowen LiBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Ximeng FengDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Chuanqing ZhouInstitute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, China.
Qiushi RenDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing, China.
Wenbin WeiBeijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0003-2386-0989

Funding

National Natural Science Foundation of China 82141128National Natural Science Foundation of China 82220108017Sanming Project of Medicine in Shenzen Municipality SZSM202311018Science & Technology Project of Beijing Municipal Science & Technology Commission Z201100005520045The Capital Health Research and Development of Special 2024-1-2052The Fund for Beijing Science & Technology Development of Traditional Chinese Medicine BJZYQN-2023-25
6 · The paper itself

Abstract

backgroundTo investigate the changes in retinal oxygen kinetics and hemodynamics in patients with choroidal melanoma (CM) within 2 years before and after iodine-125 plaque radiotherapy (PRT) using a novel noninvasive structure-functional imaging analysis system.

methodsA novel noninvasive cost-effective imaging analysis system that integrates multimodal structural and functional retinal imaging techniques has been used, which allows rapid acquisition of vascular structural, hemodynamic, and oxygenation metrics using multispectral imaging (MSI) and laser speckle contrast imaging (LSCI) techniques. Follow-ups have been arranged at the time before plaque implantation surgery, and 1 month, 3 months, 6 months, 12 months, 18 months, and 24 months after iodine-125 plaque removal.

resultsCM patients after PRT demonstrated a significant decrease in retinal arterial oxygen concentration (CO

conclusionCM patients after iodine-125 plaque radiotherapy had significant retinal and vascular changes. Future research should focus on rapidly screening radiation microvascular complications and exploring more timely and effective interventions to protect visual function in CM patients.

Indexed as

BrachytherapyChoroid NeoplasmsHemodynamicsIodine RadioisotopesMelanomaOxygenRetinaAdultAgedFemaleHumansKineticsMaleMiddle AgedRetinal VesselsIodine-125Iodine RadioisotopesOxygenchoroid melanomahemodynamicsplaque radiotherapyretinal oxygen kinetics

Identifiers

PMID40259788
PMCPMC12012311

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.