SynthesisJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Efficacy of advancement treatments of the stomatognathic system on objective sleepiness in OSA: a systematic review.
Synthesis in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mandibular advancement devices in severe obstructive sleep apnea: a second-line option that deserves greater recognition.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesObjective sleepiness is an important outcome requiring rigorous evaluation regarding obstructive sleep apnea (OSA) treatment efficacy, but no systematic review has explored the efficacy of advancement treatments of the stomatognathic system (ie, mandibular advancement device [MAD], hypoglossal nerve stimulation, and maxillomandibular advancement surgery) on objective sleepiness in OSA.
methodsWe conducted a systematic review of the literature using PubMed, Scopus, and Web of Science databases. All clinical studies assessing the efficacy of advancement treatments of the stomatognathic system on objective sleepiness in adults with OSA by the Maintenance of Wakefulness Test, the Multiple Sleep Latency Test, the Oxford Sleep Resistance Test, the Psychomotor Vigilance Task, or the Sustained Attention to Response Task were included.
resultsAmong 42 screened studies, 11 were included (6 randomized controlled trials [RCTs] and 5 prospective studies). Regarding the RCTs, all assessed MAD efficacy, and only 1 RCT found a significant improvement of objective sleepiness for MAD compared with placebo, on the Multiple Sleep Latency Test. In the remaining RCTs, the included participants did not present objective sleepiness at baseline and most had mild/moderate OSA. Regarding the prospective studies, all found a significant improvement of objective sleepiness for each treatment assessed (ie, MAD, hypoglossal nerve stimulation, maxillomandibular advancement surgery, and submental stimulation). Interestingly, the included participants in the prospective studies presented objective sleepiness at baseline and moderate/severe OSA.
conclusionsThis systematic review highlighted the lack of RCTs assessing the efficacy of MAD or other advancement treatments of the stomatognathic system on objective sleepiness in OSA. Further RCTs are needed to address this important outcome, taking into account baseline objective sleepiness and OSA severity. CITATION: Galvez P, d'Incau E, Taillard J, et al. Efficacy of advancement treatments of the stomatognathic system on objective sleepiness in OSA: a systematic review.
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