Evidence map›Paper›PMID 40259672›Full record

ArticleDrug and alcohol review2025

Changes over time in novel benzodiazepines contributing to fatal overdoses in Victoria, Australia.

Jennifer L Schumann, Rebekka Syrjanen, Jeremy A Dwyer

Abstract read
In one paragraph

Article in Drug and alcohol review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer L SchumannVictorian Institute of Forensic Medicine, Melbourne, Australia.ORCID 0000-0002-8870-6272
Rebekka SyrjanenDepartment of Forensic Medicine, Monash University, Melbourne, Australia.ORCID 0000-0002-8109-164X
Jeremy A DwyerDepartment of Forensic Medicine, Monash University, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNovel benzodiazepines (NBZN) have increased in availability and use since the mid-2000s, with a corresponding rise in associated harms including deaths.

methodsThe study used data from the Victorian Overdose Deaths Register to explore which specific NBZNs and combinations of NBZNs contributed over time to Victorian overdose deaths between January 2009 and December 2023.

resultsThere were 140 NBZN-involved overdose deaths in Victoria, with an observable increase in deaths from 2019 onward. Eight main groupings of deaths in time were identified, based on contributing NBZNs. Key groupings included etizolam-related deaths between 2019 and 2021, followed by flualprazolam and clonazolam deaths, and later, bromazolam and clobromazolam combinations in 2022-2023. DISCUSSION AND

conclusionsThese findings reflect the transiency of NBZNs in Victoria's unregulated drug market and highlight the importance of certain harm reduction measures in addressing increasing NBZN use. These include public education around the risks of using benzodiazepines not dispensed from pharmacies and the use of drug checking services to assist people obtaining benzodiazepines from unregulated drug markets.

Indexed as

BenzodiazepinesDrug OverdoseAdolescentAdultFemaleHumansMaleMiddle AgedRegistriesVictoriaYoung AdultBenzodiazepinescoronerdrug deathnew benzodiazepinenew psychoactive substance

Identifiers

PMID40259672
PMCPMC12117315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.