Evidence map›Paper›PMID 40259664›Full record

ArticleThe FEBS journal2025

The small GTPase Rap1A expedites the NOX2 oxidative burst by facilitating Rac and NOX2 autoactivations.

Hope Elizabeth Johnson, Hope Gloria Umutesi, Jongyun Heo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The FEBS journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hope Elizabeth JohnsonDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, USA.ORCID https://orcid.org/0009-0006-3913-012X
Hope Gloria UmutesiDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, USA.
Jongyun HeoDepartment of Chemistry and Biochemistry, The University of Texas at Arlington, Arlington, TX, USA.ORCID https://orcid.org/0000-0002-9430-0850

Funding

Mechanistic characterizations of redox regulations and functions of Arf and Rho familiesR15GM152973 · NIGMS · UNIVERSITY OF TEXAS ARLINGTON · PI HEO, JONGYUN · 2023 to 2024
$475k
NIGMS NIH HHS R15 GM152973NIH HHS R15GM152973
6 · The paper itself

Abstract

Rac and Rap1A are small GTPases with the redox-sensitive GX

Indexed as

NADPH Oxidase 2rac GTP-Binding Proteinsrap1 GTP-Binding ProteinsRespiratory BurstEnzyme ActivationGuanine Nucleotide Exchange FactorsHumansNADPH Oxidase 1Oxidation-ReductionSuperoxidesCYBB protein, humanGuanine Nucleotide Exchange FactorsNADPH Oxidase 1NADPH Oxidase 2PREX1 protein, humanrac GTP-Binding Proteinsrap1 GTP-Binding ProteinsSuperoxidesautoactivationNOX1NOX2RacRap1A

Identifiers

PMID40259664
PMCPMC12328082

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.