Trial reportJournal of cosmetic dermatology2025
Nanovesicles for Sensitive Skin Care Developed via Self-Assembly of Glutamine Linoleate.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Reduction of Ultraviolet- and Heat-Induced Aging Using Betulin-Loaded Arginine-Caprylate Self-Assembly: Randomized Double-Blind Clinical Trials.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Trial
- Shake-Induced Temporary Ion-Pairing Between Lecithin and Glycolic Acid for Enhanced Exfoliation in a Novel Biphasic Serum: Comparative Ex Vivo and in Vivo Randomised Studies.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Trial
- Microcarriers encapsulating COL1A1 mRNA-loaded nanovesicles for skin photoaging treatment.Materials today. Bio · 2026Article
- Exploring the impact of IL-2 cytokine family on skin barrier function: pathophysiology and therapeutic strategies.Molecular biology reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background
aimsTo investigate the effect of glutamine linoleate vesicles (QLAsomes) on skin sensitization by assessing their impact on sensitization-related protein expression, bacterial growth, and clinical efficacy in relieving skin itchiness.
methodsAfter synthesizing and analyzing QLAsomes, their inhibitory effects on capsaicin-induced cytokine expression and Staphylococcus aureus growth were evaluated. In a double-blind clinical trial, 24 participants (ages 22-63) with sensitized skin applied 10 wt% QLAsome cream on one side and a vehicle or no cream on the other twice daily for 2 weeks. Itchiness in the elbow area was assessed using a visual analog scale and expert evaluation. Skin barrier changes were measured using transepidermal water loss (TEWL), skin erythema, and stratum corneum (SC) hydration.
resultsQLAsomes, formed by
conclusionsQLAsomes showed up to 32% higher expression inhibition of key skin sensitization-related factors than individual components, and based on this, improved pruritus by 67% more than placebo. As nanovesicles with skin-soothing properties, they are effective for drug encapsulation and managing skin sensitivity in pharmaceutical and cosmetic industries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.