Evidence map›Paper›PMID 40259449›Full record

ArticleJournal of veterinary pharmacology and therapeutics2025

The Impact of Vatinoxan on the Concentrations of Medetomidine, Midazolam, and Fentanyl in Central Nervous System After Subcutaneous Co-Administration in Rats.

Juhana Honkavaara, Emily Lindh, Anna Meller, Karoliina Alm, Marja R Raekallio, Pernilla Syrjä

Abstract read
In one paragraph

Article in Journal of veterinary pharmacology and therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Juhana HonkavaaraFaculty of Veterinary Medicine, Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-8045-3549
Emily LindhFaculty of Veterinary Medicine, Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.
Anna MellerLaboratory Animal Centre, University of Helsinki, Helsinki, Finland.
Karoliina AlmLaboratory Animal Centre, University of Helsinki, Helsinki, Finland.
Marja R RaekallioFaculty of Veterinary Medicine, Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.
Pernilla SyrjäFaculty of Veterinary Medicine, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland.

Funding

Vetcare
6 · The paper itself

Abstract

Our aim was to investigate whether vatinoxan, a peripherally acting alpha

Indexed as

Adrenergic alpha-2 Receptor AntagonistsCentral Nervous SystemFentanylHypnotics and SedativesMedetomidineMidazolamAnimalsDrug InteractionsInjections, SubcutaneousMaleQuinolizinesRatsRats, WistarAdrenergic alpha-2 Receptor AntagonistsFentanylHypnotics and SedativesMedetomidineMidazolamQuinolizinesvatinoxanfentanylmedetomidinemidazolamratvatinoxan

Identifiers

PMID40259449
PMCPMC12415804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.