Evidence map›Paper›PMID 40259422›Full record

ArticleAddiction science & clinical practice2025

A novel online vaping intervention and smoking prevention program for young adults who vape: protocol for a randomized controlled trial.

Denise D Tran, Jordan P Davis, Keegan Buch, Adam M Leventhal, Sarah W Feldstein Ewing, Eric R Pedersen

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction science & clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06129123 (Development of An Online, Theory-Based Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06129123 nacompletednot on this map

Development of An Online, Theory-Based Intervention to Reduce E-cigarette Use and Susceptibility to Smoking in Young Adults: A Pilot Study

TypeinterventionalSponsorUniversity of Southern CaliforniaRan2025 to 2026Enrolled105ConditionsE-cigarette UseArmsLive Free From E-cigarettes
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The feasibility and acceptability of Live Free From E-Cigarettes (LIFFE): A web-based vaping intervention and smoking prevention program for young adults.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Denise D TranKeck School of Medicine, Department of Psychiatry and Behavioral Sciences, University of Southern California, 2250 Alcazar Street, Suite 2200, Los Angeles, CA, 90033, USA. Denise.Tran@med.usc.edu.
Jordan P DavisRAND Corporation, Santa Monica, CA, USA.
Keegan BuchKeck School of Medicine, Department of Psychiatry and Behavioral Sciences, University of Southern California, 2250 Alcazar Street, Suite 2200, Los Angeles, CA, 90033, USA.
Adam M LeventhalKeck School of Medicine, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
Sarah W Feldstein EwingSchool of Medicine, Departments of Psychiatry and Child Psychiatry. Storrs, University of Connecticut, Connecticut, USA.
Eric R PedersenKeck School of Medicine, Department of Psychiatry and Behavioral Sciences, University of Southern California, 2250 Alcazar Street, Suite 2200, Los Angeles, CA, 90033, USA.

Funding

Development of an online, theory-based intervention to reduce e-cigarette use and susceptibility to smoking in young adults: A pilot studyK01DA056699 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Denise Dao Tran · 2023 to 2026
$741k
NIDA NIH HHS K01 DA056699NIDA NIH HHS K01DA056699
6 · The paper itself

Abstract

backgroundE-cigarette use (i.e., vaping) is prevalent among young adults in the U.S. Studies show that young adults who vape are more likely to initiate cigarette smoking than young adults who do not vape. Despite this, little research on vaping interventions and prevention of smoking for young adults who vape exist.

methodsA 2-arm pilot randomized controlled trial (RCT) will be conducted by recruiting young adults ages 18-24 who reported vaping at least once per week in the past 30 days and having never smoked cigarettes at baseline. Participants will be recruited via social media ads and be randomly assigned to an intervention arm, which will be the Live Free From E-cigarettes (LIFFE) mobile-based program (n = 50), or a waitlist control arm (n = 50). The primary outcomes are biochemically verified 7-day point prevalence abstinence for nicotine vaping, vaping reduction, and smoking susceptibility. Outcomes are measured at 2-, 4-, and 8-weeks after randomization. DISCUSSION: This is the first RCT to evaluate the effectiveness of a mobile-based intervention that targets smoking susceptibility while also supporting vaping cessation or vaping reduction in young adults. Findings may inform future efforts to prevent transition to cigarette smoking and vaping cessation and reduction in young adults.

trial registrationClinicalTrials.gov: NCT06129123; Date of registration: 11/10/2023.

Indexed as

Smoking CessationSmoking PreventionVapingAdolescentElectronic Nicotine Delivery SystemsFemaleHumansMalePilot ProjectsRandomized Controlled Trials as TopicYoung AdultCessationE-cigarettesNicotinePreventionRandomized controlled trialSmokingTobaccoYoung adults

Identifiers

PMID40259422
PMCPMC12010681

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.