Evidence map›Paper›PMID 40259417›Full record

SynthesisEuropean journal of medical research2025

Impact of probiotics and polyphenols on adults with heart failure: a systematic review and meta-analysis.

Madiyar Nurgaziyev, Samat Kozhakhmetov, Zharkyn Jarmukhanov, Ayaulym Nurgaziyeva, Shynggys Sergazy, Argul Issilbayeva, Zhussipbek Mukhatayev, Symbat Seidulla, Aliya Sailybayeva, Makhabbat Bekbossynova and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Madiyar NurgaziyevLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Astana, Kazakhstan. madiyar.nurgaziyev@nu.edu.kz.
Samat KozhakhmetovLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Astana, Kazakhstan.
Zharkyn JarmukhanovLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Astana, Kazakhstan.
Ayaulym NurgaziyevaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Astana, Kazakhstan.
Shynggys SergazyLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Astana, Kazakhstan.
Argul IssilbayevaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Astana, Kazakhstan.
Zhussipbek MukhatayevLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Astana, Kazakhstan.
Symbat SeidullaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Astana, Kazakhstan.
Aliya SailybayevaCF "University Medical Center", Heart Center, Z05G9F9, Astana, Kazakhstan.
Makhabbat BekbossynovaCF "University Medical Center", Heart Center, Z05G9F9, Astana, Kazakhstan.
Almagul KushugulovaLaboratory of Microbiome, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Z05H0P9, Astana, Kazakhstan.

Funding

Ministry of Education and Science of the Republic of Kazakhstan AP23488818
6 · The paper itself

Abstract

backgroundHeart failure poses a significant health concern globally, and despite advancements in treatment, the search for additional, supportive therapeutic options remains crucial. This systematic review and meta-analysis studied the impact of probiotics and polyphenols on heart failure biomarkers, focusing on potential improvements in heart function and inflammation.

methodsWe analyzed studies published in Embase, PubMed and Cochrane library from 2012 to 2024, focusing on randomized controlled trials. Our findings are drawn from 5 studies on probiotics, involving 401 participants, and 3 studies on polyphenols with a total of 140 participants. The analysis included assessments of LVEF, hs-CRP, creatinine and NT-proBNP levels in intervention and control groups.

resultsThe probiotics or polyphenols from the included studies did not demonstrate significant changes in the health indicators analyzed for heart failure patients compared to placebo.

conclusionsThe systematic review suggested that while the concept of dietary management for heart failure is promising, further research is necessary to validate the efficacy of probiotics and polyphenols as supplementary therapies in heart failure care, by analyzing more diverse health outcomes and patient populations.

Indexed as

Heart FailurePolyphenolsProbioticsAdultBiomarkersHumansRandomized Controlled Trials as TopicBiomarkersPolyphenolsHeart failureMeta-analysisPolyphenolsProbiotics

Identifiers

PMID40259417
PMCPMC12010510

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.