Trial reportBMC musculoskeletal disorders2025
"The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients".
Trial report in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06866561 (The Effect of Aerobic Exercise on Bone Formation and Resorption Markers And The Quality of Life Tests in Postmenopausal Osteopenic Patients), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Aerobic Exercise on Bone Formation and Resorption Markers And The Quality of Life Tests in Postmenopausal Osteopenic Patients
Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effects of combined aerobic and resistance exercise on older adults with sarcopenia: a meta-analysis.BMC musculoskeletal disorders · 2026Pooled it
- A network meta-analysis of the effects of different aerobic exercise prescriptions on bone density in osteoporosis patients.Frontiers in endocrinology · 2026Pooled it
- Markers of bone turnover after 12 months of exercise in patients with chronic kidney disease 3-5: a post-hoc analysis of RENEXC - a randomized controlled trial.BMC nephrology · 2025Trial
- Cardiometabolic Health During the Climacteric Transition: A Narrative Review of Lifestyle, Physiological, and Nutritional Approaches.Healthcare (Basel, Switzerland) · 2026Review
- Exercise-induced osteoimmune crosstalk: a virtuous cycle between bone remodeling and immune regulation.Frontiers in endocrinology · 2026Review
- Age-specific association between moderate-to-vigorous physical activity and bone health: insights from a universal pDXA screening cohort in rural China.Frontiers in endocrinology · 2026Article
- Osteoporosis: molecular pathogenesis and therapeutic interventions.Molecular biomedicine · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the current study was to examine the effects of light- to moderate intensity aerobic exercise on bone mineral density (BMD) in postmenopausal osteopenic women by using bone formation and resorption markers. In the current study, P1NP and CTX levels increased in both the exercise and the control group. The aim of the current study was to examine the effects of light- to moderate-intensity aerobic exercise on bone mineral density (BMD) in postmenopausal osteopenic women by using rapidly responsive bone formation and resorption markers. PURPOSE: In this prospective, randomized, controlled, single-blind clinical study, women aged 45-65 years with BMD T scores between - 1 and - 2.5 measured by double X-ray absorptiometry (DXA) were included after evaluation of exclusion criteria and the women were divided into 2 groups: aerobic exercise group and control group (exercise, n = 25; control, n = 25). At baseline and at the 12-week follow-up, the serum levels of bone formation and resorption biomarkers, including procollagen type 1 N-terminal propeptide (P1NP), cross-linked C-telopeptide of type I collagen (CTX), osteocalcin, oxidative markers such as malondialdehyde, nonbone-specific total alkaline phosphatase, 25(OH)D3, and parathyroid hormone (PTH), were examined in all patients.
resultsA statistically significant increase in P1NP and CTX levels was noted in both the exercise and control groups at the 12-week evaluation compared to baseline (p > 0.05). Although there was no significant change in osteocalcin levels in the control group (p > 0.05), a statistically significant increase was observed in the exercise group (p < 0.05). In the exercise group, no significant changes were observed in bone formation or resorption markers, including P1NP, CTX, osteocalcin, and total ALP, or in oxidative stress markers, such as malondialdehyde, compared to those in the control group (p > 0.05).
conclusionIn conclusion, the current study revealed that regular walking exercise of light to moderate intensity significantly contributes to improvements in pain, walking speed, balance, lower extremity dynamic balance, and activities of daily living in postmenopausal women with osteopenia compared to inactive individuals.
trial registrationClinical Trial Number NCT06866561.
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