ArticleJournal of cellular and molecular medicine2025
Oncolytic Virus Infection Modulates Lysine Acetyltransferase in Gliomas: Comprehensive Analysis and Experimental Validation of KAT8 in Glioma.
Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- KAT8-mediated epigenetic modifications: Physiological functions, heterogeneity in disease, and advances in targeted development.iScience · 2026Review
- Article
- Lysine Acetyltransferase 8: A Target for Natural Compounds in Cancer Therapy.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncolytic virotherapy, which uses engineered viruses to selectively target tumour cells, has emerged as a potential treatment in glioma. However, how oncolytic virus infection modulates lactylation enzymes in gliomas remains unclear. The RNA-seq data after oncolytic virus EV-A71 infection on glioma cells was analysed to screen and lysine acetyltransferase 8 (KAT8) was selected. We analysed KAT8 expression in glioma tissues using data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. Associations between KAT8 expression and clinicopathological features were evaluated. Kaplan-Meier survival analysis and Cox regression models were used to assess the prognostic value of KAT8. Functional annotation analyses were performed to explore the KAT8-related biological processes. Single-cell RNA-sequencing data were analysed to investigate cell-type-specific KAT8 expression. In vitro experiments were conducted to validate the effects of KAT8 knockdown on apoptosis in glioma cells. KAT8 was among the top 5 down-regulated genes in glioma cells after oncolytic viruses EV-A71 infection. KAT8 was significantly overexpressed in glioma tissues compared to normal brain tissues, with higher expression in lower-grade gliomas. High KAT8 expression was associated with 1p19q co-deletion, IDH mutation, and younger patient age. Notably, high KAT8 expression correlated with better overall survival in grade IV gliomas. Functional analyses revealed KAT8's involvement in neuronal development, mRNA processing, and apoptosis regulation. Single-cell sequencing data revealed a negative correlation between KAT8 expression and apoptosis in glioblastoma cells. In vitro experiments confirmed the increased apoptosis in glioma cell lines following KAT8 knockdown. Our findings suggest that the regulatory pathway of oncolytic virus infection for lactylation enzymes may be a key pathway affecting gliomas. These findings highlight KAT8 as a potential prognostic biomarker and therapeutic target for gliomas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.