Evidence map›Paper›PMID 40259196›Full record

ArticleProbiotics and antimicrobial proteins2026

Lactobacillus salivary LSbg3 is a Potential Food Probiotic Having Excellent Anti-pathogen Effect That Might Improve Antibiotic-Resistant Diarrhea in Dogs.

Ting Zhang, Hongyu Zhong, Min Yang, Xin Shi, Liuqing Yang, Jie Yang, Haifeng Liu, Yan Luo, Yue Xie, Zhijun Zhong and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ting Zhang *College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Hongyu Zhong *College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Min Yang *Pet Nutrition and Health Research Center, Chengdu Agricultural College, Chengdu, 611130, China.
Xin Shi *Sichuan Institute of Musk Deer Breeding, Sichuan Institute for Drug Control, Chengdu, 611731, Sichuan, China.
Liuqing YangSichuan Institute of Musk Deer Breeding, Sichuan Institute for Drug Control, Chengdu, 611731, Sichuan, China.
Jie YangSichuan Institute of Musk Deer Breeding, Sichuan Institute for Drug Control, Chengdu, 611731, Sichuan, China.
Haifeng LiuCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Yan LuoCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Yue XieCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Zhijun ZhongCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Guangneng PengCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Kun ZhangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China.
Chengli ZhengSichuan Institute of Musk Deer Breeding, Sichuan Institute for Drug Control, Chengdu, 611731, Sichuan, China. zcl19861106@163.com.
Ming ZhangCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China. zhangming@sicau.edu.cn.
Ziyao ZhouCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, Sichuan, China. zzhou@sicau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotics may disrupt the intestinal microbiota balance and induce antimicrobial resistance. Although probiotics should be a priority treatment for animal diarrhea, it still has chance to be used as same/or behind as antibiotics in the clinic. Among the probiotics, Lactobacillus (Lact.) was the most frequently utilized in clinical setting since its excellent ability of safety, anti-pathogen, stress resistance, and easy colonization in intestine. In this study, we screened 24 strains of Lact. in the presence of antibiotics from clinical common antibiotic-treated feces, identified L. salivarius LSbg3 exhibiting good stress resistance, potent antibacterial activity, and exceptional intestinal adhesion capability. Its genome showed a good function of regulating intestinal nutrition while lack of transmission antibiotic-resistance genes. Additionally, in a simulated canine diarrhea with failed antibiotic treatment, LSbg3 had a good efficacy in the releasing diarrhea, balancing the microbiome and suppressing typical pathogens, positioning a potential food probiotic have excellent effect on anti-pathogen that can effectively improve antibiotic-resistant diarrhea in dogs.

Indexed as

DiarrheaDog DiseasesLactobacillusProbioticsAnimalsAnti-Bacterial AgentsDogsDrug Resistance, BacterialFecesGastrointestinal MicrobiomeAnti-Bacterial Agents16S rRNA sequencingAntibioticsBeagleDiarrheaLactobacillus salivarius LSbg3

Identifiers

PMID40259196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.