ArticleJournal of fluorescence2025
Reusable Turn-on Fluorescent Biosensor for Cardiac Biomarker Troponin I Detection Using QDs-SPION-Aptamer.
Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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3 authors.
Funding
Abstract
Tro ponin is a biomolecule found in the blood of humans that can be used as an indicator of cardiac damage and cardiovascular risk. In this study, a turn-on fluorescence-based biosensor was developed using CdSe/ZnS quantum nanoparticles with high fluorescence efficiency decorated on superparamagnetic nanoparticles and aptamer as a probe for cardiac troponin I detection to improve fluorescence efficiency and create a reusable sensor through magnetic separation. Chemical modifications of biosensor components have been characterized by zeta sizer, zeta potential, UV-Vis spectroscopy, transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). We reported that the developed sensor worked with a "Turn-on" mechanism. Fluorescence changes of the developed aptamer-based biosensor were evaluated using a fluorometer, and a low limit of detection (LOD) of 13.3 ng/ml with a linear detection range from 2 to 40 ng/ml was determined. Additionally, the selectivity and sensitivity of the biosensor have been tested with several biomarkers found in human blood.
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