Evidence map›Paper›PMID 40259166›Full record

ArticleJournal of neurovirology2025

Progressive multifocal leukoencephalopathy during 4 years of Palbociclib for advanced breast cancer with a history of follicular lymphoma patient.

Ryosuke Koyamada, Mariko Nishihara, Tetsuhiro Masaki, Tomohito Shimada, Kazuhiro Ishikawa, Jun Hashimoto, Nobuyoshi Mori, Asami Namai, Hideaki Yokoo, Kenta Takahashi and 3 more

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In one paragraph

Article in Journal of neurovirology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ryosuke KoyamadaDepartment of Hematology, St. Luke's International Hospital, Tokyo, Japan. koyaryo@luke.ac.jp.
Mariko NishiharaDepartment of Hematology, St. Luke's International Hospital, Tokyo, Japan.
Tetsuhiro MasakiDepartment of Hematology, St. Luke's International Hospital, Tokyo, Japan.
Tomohito ShimadaDepartment of Hematology, Yokosuka Kyosai Hospital, Yokosuka, Japan.
Kazuhiro IshikawaDepartment of Infectious Disease, St. Luke's International Hospital, Tokyo, Japan.
Jun HashimotoDepartment of Medical Oncology, St. Luke's International Hospital, Tokyo, Japan.
Nobuyoshi MoriDepartment of Infectious Disease, St. Luke's International Hospital, Tokyo, Japan.
Asami NamaiDepartment of Pathology, St. Luke's International Hospital, Tokyo, Japan.
Hideaki YokooDepartment of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Kenta TakahashiDepartment of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Tadaki SuzukiDepartment of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Kazuo NakamichiDepartment of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
Shinichiro MoriDepartment of Hematology, St. Luke's International Hospital, Tokyo, Japan.

Funding

JSPS KAKENHI grant no. 21K07450the Research Committee of Prion Disease and Slow Virus Infection, Research on Policy Planning and Evaluation for Rare and Intractable Diseases, Health and Labour Sciences Research Grants, the Ministry of Health, Labour and Welfare, Japan 23FC1007
6 · The paper itself

Abstract

A 67-year-old woman with a history of follicular lymphoma and recurrent breast cancer with multiple metastasis developed PML during receiving fluvestrant plus palbociclib. Rituximab and bendamustine had finished 6.5 years ago. Discontinuing palbociclib and using mirtazapine, she is alive a year after diagnosis of PML. It is rare for PML to be diagnosed long after the last dose of rituximab and bendamustine. We will discuss the possible involvement of palbociclib in the course of PML.

Indexed as

Breast NeoplasmsLeukoencephalopathy, Progressive MultifocalLymphoma, FollicularPiperazinesPyridinesAgedAntineoplastic Combined Chemotherapy ProtocolsBendamustine HydrochlorideFemaleHumansMianserinMirtazapineRituximabBendamustine HydrochlorideMianserinMirtazapinepalbociclibPiperazinesPyridinesRituximabBreast cancerCDK4/6 inhibitorJC virusPalbociclibProgressive multifocal leukoencephalopathy

Identifiers

PMID40259166
PMCPMC12137487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.