Evidence map›Paper›PMID 40259155›Full record

ArticleJournal of ophthalmic inflammation and infection2025

Bilateral acute multifocal retinitis and retinal vasculitis secondary to Rickettsia typhi infection.

Weilin Song, Adrian Au, David Sarraf, Pradeep Prasad, Edmund Tsui

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Article in Journal of ophthalmic inflammation and infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Weilin SongStein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA.
Adrian AuStein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA.
David SarrafStein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA.
Pradeep PrasadStein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA.
Edmund TsuiStein Eye Institute, Department of Ophthalmology, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA, 90095, USA. etsui@mednet.ucla.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe a case of acute multifocal retinitis (AMR) and retinal vasculitis associated with Rickettsia typhi.

methodsCase report.

resultsA 37-year-old previously healthy female presented with acute bilateral panuveitis that was preceded by a febrile illness with pneumonitis and transaminitis. On exam she had bilateral multifocal small white retinal lesions, vascular sheathing, and hemorrhages. The retinal lesions, which appeared consistent with infiltrates and/or ischemia, were confined within the inner or middle retinal layers on optical coherence tomography (OCT) and corresponded to late leakage on fluorescein angiography (FA). There was no evidence of choroidal involvement on indocyanine green angiography (ICGA). Based on the imaging findings and history, the diagnosis of AMR with associated small vessel retinal vasculitis was made and the patient was started empirically on doxycycline. Workup was positive for R. typhi. At follow-up, there was resolution of visual symptoms and nearly all retinal lesions.

conclusionsRickettsial disease should be highly suspected in a patient with AMR and occlusive small vessel vasculitis. Retinal lesions may be either infiltrative or ischemic in nature. Diagnosis, which can be aided by multimodal retinal imaging, is essential for prompt initiation of appropriate antibiotic therapy.

Indexed as

Acute multifocal retinitisRickettsiaTyphus

Identifiers

PMID40259155
PMCPMC12011691

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