Evidence map›Paper›PMID 40259151›Full record

ArticleGeroScience2026

Sex differences in body mass index and waist circumference trajectories and dementia risk: the HUNT4 70+ study.

Ekaterina Zotcheva, Bjørn Heine Strand, Vegard Skirbekk, Kay Deckers, Steinar Krokstad, Gill Livingston, Archana Singh-Manoux, Geir Selbæk

Erratum issuedAbstract read
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In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Effects of obesity on brain health and cognition.Nature reviews. Neurology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Ekaterina ZotchevaNorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Aldring Og Helse, PO Box 2136, 3103, Tønsberg, Norway. ekaterina.zotcheva@aldringoghelse.no.ORCID 0000-0002-5777-4731
Bjørn Heine StrandNorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Aldring Og Helse, PO Box 2136, 3103, Tønsberg, Norway.
Vegard SkirbekkNorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Aldring Og Helse, PO Box 2136, 3103, Tønsberg, Norway.
Kay DeckersDepartment of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute (MHeNs), Alzheimer Centrum Limburg, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.
Steinar KrokstadDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, HUNT Research Centre, Norwegian University of Science and Technology, PO Box 8905, 7491, Trondheim, Norway.
Gill LivingstonDivision of Psychiatry, University College London, 149 Tottenham Ct Rd, London, W1 T7 NF, UK.
Archana Singh-ManouxDivision of Psychiatry, University College London, 149 Tottenham Ct Rd, London, W1 T7 NF, UK.
Geir SelbækNorwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Aldring Og Helse, PO Box 2136, 3103, Tønsberg, Norway.

Funding

European Research Council 101142786 - HOMMEFoundation for the National Institutes of Health R01: R01AG069109-01Helse Sør-Øst RHF 2022053
6 · The paper itself

Abstract

We examined associations between body mass index (BMI), waist circumference (WC), and dementia risk, and differences in BMI and WC trajectories before dementia diagnosis. We included 9,739 participants (54% women) aged 70+ from the Trøndelag Health Study (HUNT4 70+). BMI was measured four times (1984-2019) and WC three times (1995-2019). Dementia diagnoses were clinically assessed at HUNT4 70+ . Women and men with dementia had higher midlife BMI and WC than those without dementia. These differences diminished closer to diagnosis, especially in women. Midlife obesity in both sexes and midlife overweight, high WC, and overweight/obesity with high WC in men were linked to higher dementia risk. Lower dementia risk was observed with late-life overweight for both sexes, late-life high WC in women, late-life overweight/obesity with normal WC in men or high WC in women. Adiposity measures and their changes influence dementia risk differently in women and men.

Indexed as

Body Mass IndexDementiaWaist CircumferenceAgedAged, 80 and overFemaleHumansMaleNorwayObesityOverweightRisk FactorsSex FactorsAdiposityAnthropometric measuresCognitive impairmentLife-course perspectivePopulation-based study

Identifiers

PMID40259151
PMCPMC12972498

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.