Evidence map›Paper›PMID 40259125›Full record

ArticleEuropean journal of epidemiology2025

The baseline examinations of the German National Cohort (NAKO): recruitment protocol, response, and weighting.

Stefan Rach, Matthias Sand, Achim Reineke, Heiko Becher, Karin Halina Greiser, Kathrin Wolf, Kerstin Wirkner, Carsten Oliver Schmidt, Sabine Schipf, Karl-Heinz Jöckel and 32 more

Abstract read
In one paragraph

Article in European journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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  5. Intensity-specific physical activity and mortality in 147,414 adults: a pooled accelerometer analysis.The international journal of behavioral nutrition and physical activity · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Stefan RachDepartment of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstr. 30, 28359, Bremen, Germany. rach@leibniz-bips.de.ORCID http://orcid.org/0000-0001-5241-0253
Matthias SandDepartment of Survey Design and Methodology, GESIS-Leibniz Institute for the Social Sciences, Mannheim, Germany.
Achim ReinekeDepartment of Biometry and Data Management, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.ORCID http://orcid.org/0000-0002-0092-4110
Heiko BecherInstitute of Global Health, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-8808-6667
Karin Halina GreiserDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kathrin WolfInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4343-201X
Kerstin WirknerLeipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0009-0000-1301-7125
Carsten Oliver SchmidtInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Sabine SchipfInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-2700-5317
Karl-Heinz JöckelDepartment of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstr. 30, 28359, Bremen, Germany.ORCID http://orcid.org/0000-0002-1987-0255
Lilian KristInstitute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Wolfgang AhrensDepartment of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstr. 30, 28359, Bremen, Germany.ORCID http://orcid.org/0000-0003-3777-570X
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stefanie CastellDepartment of Epidemiology, Helmholtz Centre for Infection Research (HZI), Brunswick, Germany.ORCID http://orcid.org/0000-0003-1762-8462
Sylvia GastellGerman Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Volker HarthInstitute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-4308-223X
Bernd HolleczekSaarland Cancer Registry, Saarbrücken, Germany.ORCID http://orcid.org/0000-0001-8759-4371
Till IttermannInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-0154-7353
Stefan Janisch-FabianDepartment of Biometry and Data Management, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany.
André KarchInstitute of Epidemiology and Social Medicine, Münster, Germany.
Thomas KeilInstitute of Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-9108-3360
Carolina J Klett-TammenDepartment of Epidemiology, Helmholtz Centre for Infection Research (HZI), Brunswick, Germany.ORCID http://orcid.org/0000-0001-9685-5369
Alexander KluttigInstitute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther University Halle-Wittenberg, Halle (Saale), Germany.ORCID http://orcid.org/0000-0003-4446-9938
Oliver KußGerman Diabetes Center (DDZ), Institute for Biometrics and Epidemiology, Düsseldorf, Germany.ORCID http://orcid.org/0000-0003-3301-5869
Michael LeitzmannDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Wolfgang LiebInstitute of Epidemiology, Kiel University, Kiel, Germany.ORCID http://orcid.org/0000-0003-2544-4460
Claudia Meinke-FranzeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-6137-9702
Karin B MichelsInstitute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
Rafael MikolajczykInterdisciplinary Center for Health Sciences, Medical Faculty of the Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany.ORCID http://orcid.org/0000-0003-1271-7204
Ilais Moreno VelásquezMolecular Epidemiology Research Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID http://orcid.org/0000-0001-6058-8983
Nadia ObiInstitute for Occupational and Maritime Medicine (ZfAM), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-0903-9142
Cara ÖvermöhleInstitute of Epidemiology, Kiel University, Kiel, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.
Tobias PischonMolecular Epidemiology Research Group, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.ORCID http://orcid.org/0000-0003-1568-767X
Susanne RospleszczInstitute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4788-2341
Börge SchmidtInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Matthias B SchulzeGerman Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.ORCID http://orcid.org/0000-0002-0830-5277
Andreas StangInstitute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Henning TeismannInstitute of Epidemiology and Social Medicine, Münster, Germany.ORCID http://orcid.org/0000-0001-5807-5572
Christine TöpferDepartment of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
Robert WolffTrusted Third Party of the University Medicine Greifswald, Greifswald, Germany.
Kathrin GüntherDepartment of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstr. 30, 28359, Bremen, Germany.ORCID http://orcid.org/0000-0003-3801-4769

Funding

Bundesministerium für Bildung und Forschung 01ER1301A/B/CBundesministerium für Bildung und Forschung 01ER1511DBundesministerium für Bildung und Forschung 01ER1801A/B/C/DBundesministerium für Bildung und Forschung 01ER2301A/B/C
6 · The paper itself

Abstract

The German National Cohort (NAKO) is the largest population-based epidemiologic cohort study in Germany and investigates the causes of the most common chronic diseases. Between 2014 and 2019, a total of 1.3 million residents aged 20-69 years from 16 German regions were randomly selected from the general population and invited to participate following a highly standardized recruitment protocol. The overall response was 15.6% and differed considerably across study centers (7.6-30.7%). Females were more likely to participate than males (17.5% vs. 14.1%) and participation increased with age (10.2% in age group " < 29 years" up to 20.7% in age group " > 60 years"). Across all study regions, response was highest in rural areas (22.3%), followed by towns and suburbs (17.2%), and was lowest in cities (14.5%). Compared with the general population in the respective study regions, participants with low and medium education are underrepresented in the NAKO sample, while highly educated participants are overrepresented. Participants with non-German nationality and with a migration background are also underrepresented. Participants living in single households are underrepresented, while participants from larger households (2 or more persons) are overrepresented compared to the general population. Survey weights are made available to researchers along with the study data that account for the sampling design and adjust for differences in the distribution of age, sex, nationality (German vs. non-German), migration status, education, and household size.

Indexed as

Patient SelectionAdultAgedChronic DiseaseCohort StudiesFemaleGermanyHumansMaleMiddle AgedYoung AdultCohort studiesCorrection weightsEpidemiologyNonresponseParticipationPopulation-basedResponseSample designSurvey weights

Identifiers

PMID40259125
PMCPMC12145326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.