Risk factors for the persistence of unruptured intracranial vertebral artery dissecting aneurysms treated with flow diverters.

Jiangli Han, Xiaobo Li, Hao Niu, Long Lin, Aihua Liu, Ying Xia

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jiangli HanDepartment of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, No.43 Renmin Avenue, Meilan District, Haikou, 570208, Hainan Province, China.

Xiaobo LiDepartment of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, No.43 Renmin Avenue, Meilan District, Haikou, 570208, Hainan Province, China.

Hao NiuBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Long LinDepartment of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, No.43 Renmin Avenue, Meilan District, Haikou, 570208, Hainan Province, China.

Aihua LiuBeijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. liuaihuadoctor@163.com.

Ying XiaDepartment of Neurosurgery, Affiliated Haikou Hospital, Xiangya School of Medicine, Central South University, No.43 Renmin Avenue, Meilan District, Haikou, 570208, Hainan Province, China. xiaying008@163.com.

Funding

Beijing Municipal Administration of Hospitals' Ascent Plan DFL20190501Beijing Natural Science Foundation 19L2013; 22G10396BTH Coordinated Development-Beijing Science and Technology Planning Project Z181100009618035Hainan Province Clinical Medical Research Center LCYX202107National Natural Science Foundation of China 81771233Research and Promotion Program of Appropriate Techniques for Intervention of Chinese High-risk Stroke People GN-2020R0007

6 · The paper itself

Abstract

Flow diverters (FDs) have been employed in the treatment of unruptured intracranial vertebral artery dissecting aneurysms (IVADAs), yielding seemingly favorable outcomes. Despite FD treatment, aneurysm persistence (incomplete occlusion post-initial treatment) can occur in some patients, potentially leading to recurrent symptoms or complications. This study aims to explore the risk factors associated with the persistence of unruptured IVADAs that have undergone treatment with FDs. The study encompassed 77 unruptured IVADAs from 75 consecutive patients who received treatment with FDs. At a median follow-up of 13 months, 31.2% (24/77) of IVADAs exhibited persistence. Upon multivariate logistic regression analysis, significant pre-procedural stenosis adjacent to aneurysmal dilatation (odds ratio [OR] 17.02, 95% confidence interval [CI] 2.01-144.24, p = 0.009) and posterior inferior cerebellar artery involvement (OR 7.06, 95% CI 1.40-35.50, p = 0.018) were independently associated with aneurysm persistence; while follow-up duration (OR 0.91, 95% CI 0.84-0.97, p = 0.005) was adversely associated with aneurysm persistence. Significant pre-procedural stenosis adjacent to aneurysmal dilatation and posterior inferior cerebellar artery involvement could serve as independent risk factors contributing to the persistence of unruptured IVADAs after FD treatment..

Indexed as

Endovascular ProceduresIntracranial AneurysmVertebral ArteryVertebral Artery DissectionAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesRisk FactorsStentsTreatment OutcomeDissecting aneurysmFlow diverterStenosisTherapeutic occlusionVertebral artery

Identifiers

PMID40258996

DOI10.1038/s41598-025-98737-y

PMCPMC12012210

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.