Evidence map›Paper›PMID 40258995›Full record

ArticleBone marrow transplantation2025

Feasibility and efficacy of partial replacement of post transplantation cyclophosphamide with bendamustine on day +4 for graft versus host disease prophylaxis in patients undergoing allogeneic hematopoietic cell transplantation.

Velu Nair, Manthan Kathrotiya, Vijaykumar Shirure, Shruti Bhise, Sandip Kheni, Jayani Patel, Neha Motwani, Dhara Shah, Grishma Sukhwal, Chaitrangi Paranjape and 4 more

Abstract read
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In one paragraph

Article in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Velu NairDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India. drvelunair@gmail.com.ORCID 0000-0002-8710-1925
Manthan KathrotiyaDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India.
Vijaykumar ShirureDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India.
Shruti BhiseDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India.
Sandip KheniDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India.
Jayani PatelDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India.
Neha MotwaniDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India.
Dhara ShahDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India.
Grishma SukhwalDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India.
Chaitrangi ParanjapeDepartment of Clinical Haematology, BMT, and Cellular Therapy, Apollo Hospital International Limited, Gandhinagar, India.
Vivek NairDr Nair's Skin Clinic and Hair Transplant Centre, Gurgaon, India.
Anshul WarmanDepartment of Dermatology, Apollo Hospital International Limited, Gandhinagar, India.
Seema PatrikarDepartment of Bio-statistics, Armed Forces Medical College (AFMC), Pune, India.
Uday YanamandraDepartment of Medicine, Armed Forces Medical College (AFMC), Pune, India.ORCID 0000-0002-0546-6585

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PT-CY use in T cell-replete haploidentical HCT has significantly improved outcomes. However, hyperhydration with MESNA in CY administration poses a challenge, in patients with cardiac/ renal problems. PT-CY also increases VOD risk with prior exposure to hepatotoxic drugs. Katsanis et al. in a phase Ia trial in patients undergoing HCT for hematological malignancies showed that partially replacing PT-CY with PT-BEN had comparable outcomes to conventional PT-CY. We conducted an ambispective study in 54 patients [haplo (39), MSD(14), and MUD(1)] with nonmalignant hematological disorders and hematological malignancies in pediatric and adult patients undergoing HCT (MAC/RIC) from February 2019 to May 2024. GvHD prophylaxis comprised of PT-CY/BEN (PT-CY 50 mg/kg Day +3; PT-BEN 90 mg/m

Indexed as

Bendamustine HydrochlorideCyclophosphamideGraft vs Host DiseaseHematopoietic Stem Cell TransplantationTransplantation ConditioningAdolescentAdultAgedChildChild, PreschoolFeasibility StudiesFemaleHematologic NeoplasmsHumansMaleMiddle AgedBendamustine HydrochlorideCyclophosphamide

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.