ArticleNature cell biology2025
Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism.
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Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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16citing papers in PubMed
–field-weighted citation impact
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- The diversity of terminal electron acceptors across eukaryotes.Trends in biochemical sciences · 2026Review
- Defining Rational Photoelectron Routing for Targeted Intracellular Energy Transfer.Angewandte Chemie (International ed. in English) · 2026Article
- Gut microbiota-derived indole-3-propionic acid alleviates endoplasmic reticulum stress by regulating FMO2 in MASLD.Hepatology communications · 2026Article
- Metabolic robustness is an emergent property of hierarchical network organization in yeast.mSystems · 2026Article
- Real-time electrical monitoring of enzymatic catalytic dynamics at the single-molecule level.Nature communications · 2026Article
- Mitochondrial NADK2-dependent NADPH controls tau oligomer uptake in human neurons.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cells Engage Endogenous Malonate Synthesis to Drive Mitochondrial Metabolism.bioRxiv : the preprint server for biology · 2026Article
- CcAbl1 is required for virulence via regulating NADPH-glutathione-mediated redox balance in Cytospora chrysosperma.Stress biology · 2026Article
- Toward sustainable food preservatives: high-level production of sorbic acid in engineered Saccharomyces cerevisiae.Nature communications · 2026Article
- Whole-transcriptome analysis of Aortic Stenosis reveals dysregulated RNA networks, immune cell infiltration, and NADK2 as a candidate regulator.Hereditas · 2026Article
- UFMylation of Pyruvate Dehydrogenase Regulates Mitochondrial Metabolism.bioRxiv : the preprint server for biology · 2026Article
- SOX8/CPT2 axis regulates lipid metabolism to support enzalutamide resistance in prostate cancer.Cancer cell international · 2026Article
- Cooperative Architecture of Mitochondrial Proteome Homeostasis.medRxiv : the preprint server for health sciences · 2026Article
- Mitochondrial phosphopantetheinylation is required for oxidative metabolism.Metabolism: clinical and experimental · 2026Article
- Hyperuricemia was associated with metabolic response against brain injury instead of metabolism syndrome in Tibet: a cross-sectional analysis.Frontiers in endocrinology · 2026Article
- NADK Governs Ferroptosis Susceptibility by Orchestrating NADPH Homeostasis.Antioxidants (Basel, Switzerland) · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
21 authors.
Dohun KimChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-6060-0601
Rushendhiran KesavanChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Kevin RyuChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0009-0005-8836-2720
Trishna DeyChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Austin MarckxLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Cameron MenezesChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Prakash P PraharajChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Stewart MorleyDonald Danforth Plant Science Center, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5340-7945
Bookyung KoChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mona H SoflaeeChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Harrison J TomChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Harrison BrownChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Hieu S VuChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shih-Chia TsoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Chad A BrautigamDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Andrew LemoffDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Marcel MettlenDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Prashant MishraChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0003-2223-1742
Feng CaiChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Doug K AllenDonald Danforth Plant Science Center, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-8599-8946
Gerta HoxhajChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA. gerta.hoxhaj@utsouthwestern.edu.ORCID http://orcid.org/0000-0001-6179-3583
Funding
UT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Kathryn Ann O'Donnell · 2010 to 2026
$53.7MUT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Jeffrey M Zigman · 2022 to 2026
$7.4MRevealing the essential functions of mitochondrial NADPH and NADK2 for cell growth and proliferationR01GM143236 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI HOXHAJ, GERTA N/A · 2021 to 2025
$1.8MDecoding the metabolic routes of purine nucleotides in cancer - Resubmission - 1R01CA289251 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Gerta N/A Hoxhaj · 2025 to 2026
$1.1MThe role of mitochondrial ATP production in liver failureF30DK137407 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Cameron Joseph Menezes · 2024 to 2026
$131kAmerican Cancer Society (American Cancer Society, Inc.) RSG-22-177-01-TBECancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP210041Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RP240035Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas) RR190087NCI NIH HHS P30 CA142543NCI NIH HHS R01 CA289251NIDDK NIH HHS F30 DK137407NIDDK NIH HHS P30 DK127984NIGMS NIH HHS R01 GM143236Pew Charitable Trusts 00036920United States Department of Agriculture | Agricultural Research Service (USDA Agricultural Research Service) 2021-67013-33778U.S. Department of Health & Human Services | National Institutes of Health (NIH) S10OD030312-01U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1R01CA289251-01A1U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK137407U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 3R01GM143236-02S1U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM143236V Foundation for Cancer Research (V Foundation) V2021-019Welch Foundation I-2067-20240404
Abstract
Nicotinamide adenine dinucleotide phosphate (NADPH) is a vital electron donor essential for macromolecular biosynthesis and protection against oxidative stress. Although NADPH is compartmentalized within the cytosol and mitochondria, the specific functions of mitochondrial NADPH remain largely unexplored. Here we demonstrate that NAD
Indexed as
Fatty AcidsLipoylationMitochondriaNADPPhosphotransferases (Alcohol Group Acceptor)AnimalsHumansMiceMice, KnockoutOxidation-ReductionOxidative StressFatty AcidsNAD kinaseNADPPhosphotransferases (Alcohol Group Acceptor)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.