Evidence map›Paper›PMID 40258922›Full record

ArticleScientific reports2025

The value of the CRP-albumin-lymphocyte index (CALLY index) as a prognostic biomarker in acute ischemic stroke.

Yinghuan Pan, Zeyu Liu, Ruxin Tu, Xianjing Feng, Fang Yu, Minping Wei, Jie Feng, Weijia Xie, Bi Deng, Jian Xia and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. First-Trimester Maternal CALLY Index Is Associated With Fetal Growth Restriction.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yinghuan Pan *Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zeyu Liu *Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ruxin TuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xianjing FengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Fang YuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Minping WeiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jie FengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Weijia XieDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Bi DengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jian XiaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jun YinDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China. 405821@csu.edu.cn.

Funding

the National Key Research and Development Projects 2022YFC3602400the National Natural Science Foundation of China 82271369
6 · The paper itself

Abstract

This study aims to evaluate the predictive capability of CRP-albumin-lymphocyte (CALLY) index in relation to hemorrhagic transformation (HT) and functional outcome in acute ischemic stroke (AIS). A total of 439 AIS patients were included in this analysis. Multivariate logistic regression was conducted to examine the relationship between the CALLY index, HT, and functional outcomes. To address its non-linear association, a restricted cubic spline (RCS) model identified an optimal threshold for the CALLY index. Subgroup analyses further explored the association between the CALLY index and HT. The receiver operating characteristic (ROC) curve, the net reclassification index (NRI), and the integrated discrimination index (IDI) were used to assess and compare the predictive performance of the CALLY index with established models for HT. Furthermore, mediation analysis was performed to elucidate the causal pathways linking the CALLY index, HT, and functional outcomes. Among the participants, 9.79% (43/439) experienced HT, and 49.32% (182/369) encountered adverse outcomes. A higher CALLY index was associated with a lower risk of developing HT (OR 0.449, 95% CI 0.283-0.713) and poor outcome (OR 0.691, 95% CI 0.558-0.855). RCS curves demonstrated an increased risk of HT when the CALLY index fell below 1.188. Compared to existing HT prediction models, the CALLY index demonstrates superior predictive performance, with an AUC of 0.746. Furthermore, the CALLY index exhibits improved reclassification ability, as indicated by enhanced NRI and IDI values. The CALLY index independently predicts HT and adverse outcomes in AIS, demonstrating superior accuracy to existing risk scores and offering a practical biomarker for clinical prognosis.

Indexed as

C-Reactive ProteinIschemic StrokeLymphocytesSerum AlbuminAgedAged, 80 and overBiomarkersFemaleHumansMaleMiddle AgedPrognosisROC CurveBiomarkersC-Reactive ProteinSerum AlbuminHemorrhagic transformationImmunityInflammationPrognosisStroke

Identifiers

PMID40258922
PMCPMC12012108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.