Evidence map›Paper›PMID 40258871›Full record

SynthesisScientific reports2025

A systematic review and network meta-analysis of surgical interventions for glaucoma following penetrating keratoplasty.

Ssu-Yu Pan, Yun-Yu Chen, Yi-An Lu, Hsuan-En Huang, Peng-Tai Tien, Hui-Ju Lin, Chun-Yuan Wang, Chia-Jen Chang, I-Jong Wang, Chien-Chih Chou

Abstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ssu-Yu PanSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yun-Yu ChenDepartment of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Yi-An LuDepartment of Ophthalmology, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Xitun District, Taichung, Taiwan.
Hsuan-En HuangDepartment of Ophthalmology, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Xitun District, Taichung, Taiwan.
Peng-Tai TienSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Hui-Ju LinEye Center, China Medical University Hospital, Taichung, Taiwan.
Chun-Yuan WangDepartment of Ophthalmology, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Xitun District, Taichung, Taiwan.
Chia-Jen ChangDepartment of Ophthalmology, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Xitun District, Taichung, Taiwan.
I-Jong WangGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Chien-Chih ChouSchool of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. doctorccc@gmail.com.

Funding

Taichung Veterans General Hospital TCVGH-1136902B
6 · The paper itself

Abstract

This study aims to compare the effectiveness and safety of surgical interventions for secondary glaucoma following penetrating keratoplasty (PKP) through a network meta-analysis. PubMed, Cochrane Central Register of Controlled Trials, Embase, Web of Science, Scopus, and Google Scholar databases were searched for articles published from inception to July 16, 2024. We included studies that compared the effects of trabeculectomy, glaucoma drainage devices (GDDs), or cyclophotocoagulation (CPC) on graft failure, intraocular pressure (IOP), or the number of glaucoma medications required for patients with post-PKP glaucoma. Based on data synthesized from 13 cohort studies, we observed that valved GDDs are not associated with a higher risk of graft failure (risk ratio [RR], 1.49; 95% confidence interval [CI], 0.89 to 2.48) compared with trabeculectomy with antifibrotic agents. Valved GDDs demonstrated greater benefits in achieving successful IOP control (RR, 1.33; 95% CI, 1.08 to 1.64), reducing IOP from baseline (mean difference [MD], - 3.08; 95% CI, - 5.36 to - 0.81), and reducing the number of glaucoma medication usage from baseline (MD, - 0.53; 95% CI, - 0.94 to - 0.12) compared with trabeculectomy with antifibrotic agents. In conclusion, valved GDDs may be the preferred surgical option for managing post-PKP glaucoma.

Indexed as

GlaucomaKeratoplasty, PenetratingPostoperative ComplicationsGlaucoma Drainage ImplantsHumansIntraocular PressureTrabeculectomyTreatment OutcomeCyclophotocoagulationGlaucoma drainage devicePenetrating keratoplastySecondary glaucomaTrabeculectomy

Identifiers

PMID40258871
PMCPMC12012029

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.