ArticleNature communications2025
Electron transfer engineering of artificially designed cell factory for complete biosynthesis of steroids.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Programming Bio-Bio Electronic Interfaces for Light-Driven Interspecies Electron Transfer.Angewandte Chemie (International ed. in English) · 2026Article
- Mitochondrial complex I as a master regulator of redox signaling: From structural architecture to directionality of electron transport.Free radical biology & medicine · 2026Review
- Engineering of plant-derived P450scc forSynthetic and systems biotechnology · 2026Article
- Stable loci and functional gene controlling pod shattering resistance across multiple environments under different genetic backgrounds in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Advances in the microbial biosynthesis of therapeutic terpenoids.Current opinion in biotechnology · 2025Review
- Rieske Oxygenases: Powerful Models for Understanding Nature's Orchestration of Electron Transfer and Oxidative Chemistry.Biochemistry · 2025Review
- Improving Cofactor Promiscuity of HMG-CoA Reductase fromBiomolecules · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biosynthesis of steroids by artificially designed cell factories often involves numerous nicotinamide adenine dinucleotide phosphate (NADPH)-dependent enzymes that mediate electron transfer reactions. However, the unclear mechanisms of electron transfer from regeneration to the final delivery to the NADPH-dependent active centers limit systematically engineering electron transfer to improve steroids production. Here, we elucidate the electron transfer mechanisms of NADPH-dependent enzymes for systematically engineer electron transfer of Saccharomyces cerevisiae, including step-by-step engineering the electron transfer residues of 7-Dehydrocholesterol reductase (DHCR7) and P450 sterol side chain cleaving enzyme (P450
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