ArticleNPJ Parkinson's disease2025
Parkinson's disease with possible REM sleep behavior disorder correlated with more severe glymphatic system dysfunction.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Trial
- MRI Diffusion Tensor Image Analysis Along the Perivascular Space: Effects of Mean Tract Orientation Divergence.Journal of magnetic resonance imaging : JMRI · 2026Article
- Glymphatic system dysfunction: a link between sleep disorders and neurodegeneration.Psychopharmacology · 2026Review
- Association between obstructive sleep apnea severity and glymphatic-related DTI-ALPS alterations in newly diagnosed, Drug-Naïve Alzheimer's disease.The journal of prevention of Alzheimer's disease · 2026Article
- Plasma ceramide ratios define metabolic-inflammatory associations with cognitive impairment in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Regional wasteosome accumulation across neurodegenerative diseases points to a shared underlying mechanism potentially related to glymphatic insufficiency.Acta neuropathologica communications · 2026Article
- Associations of DTI-ALPS index and choroid plexus volume with clinical severity across the Parkinson's disease spectrum.NPJ Parkinson's disease · 2026Article
- Exercise Intervention for REM Sleep Behavior Disorder in Parkinson's Disease: Mechanisms and Implications for Neurorehabilitation.CNS neuroscience & therapeutics · 2026Review
- Role of glymphatic system function in cognitive dysfunction among patients with bipolar disorder.The international journal of neuropsychopharmacology · 2026Article
- Characteristics and mechanisms of cognitive impairment in Parkinson disease.Nature reviews. Neurology · 2026Review
- Glymphatic dysfunction and its association with clinical symptom severity in narcolepsy type 1: a case-control DTI-ALPS study.BMC neurology · 2026Article
- Aquaporin-4 mis-localization decreases glymphatic clearance of α-synuclein in an alpha-syntrophin knock out mouse model and promotes α-synuclein pathology and aggregate propagation.Brain communications · 2026Article
- Manifestations of different sleep disorders in patients with vascular parkinsonism and their impact on prognosis.American journal of translational research · 2026Article
- A systematic review and meta-analysis on glymphatic flow dysfunction in Parkinson's disease and Parkinsonism spectrum.NPJ Parkinson's disease · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the glymphatic system activity in Parkinson's disease (PD) with and without rapid eye movement sleep behavior disorder (RBD) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods. Overall, 91 patients with PD and 33 healthy controls were recruited. PD patients were divided into PD-RBD (n = 55) and PD-nRBD (n = 36) groups according to RBD scales. The ALPS-index and enlarged perivascular spaces (EPVS) scores were calculated. PD-RBD group exhibited lower ALPS-index than PD-nRBD and controls after controlling for the effect of age (p = 0.018 and p = 0.001). PD-RBD group showed higher UPDRS part I and HAMD score than those in PD-nRBD group. RBD symptom was independently correlated with ALPS-index in PD (β = -0.259, p = 0.014). In conclusion, PD with possible RBD correlated with more severe glymphatic system dysfunction and non-motor symptoms than those in PD without RBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.