Evidence map›Paper›PMID 40258513›Full record

ArticleChest2025

Association of Physical Frailty With Incidence and Life Expectancy of COPD: A Population-Based Cohort Study.

Chao Liu, Hui Xiong, Xia Han, Yanling Lv, Decai Wang, Jiannan Hu, Ziling Li, Xinyue Ma, Yunfei Zhu, Shuyun Xu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Residential Green and Blue Space, the Natural Environment, Genetic Susceptibility, and Incident COPD.International journal of chronic obstructive pulmonary disease · 2026
    Article
  4. Article
  5. Response.Chest · 2025
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chao LiuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Respiratory Diseases, National Ministry of Health of the People's Republic of China and National Clinical Research Center for Respiratory Disease, Wuhan, China.
Hui XiongCardiac Function Department, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
Xia HanCardiac Function Department, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
Yanling LvDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Decai WangDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Respiratory Diseases, National Ministry of Health of the People's Republic of China and National Clinical Research Center for Respiratory Disease, Wuhan, China.
Jiannan HuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Respiratory Diseases, National Ministry of Health of the People's Republic of China and National Clinical Research Center for Respiratory Disease, Wuhan, China.
Ziling LiDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Respiratory Diseases, National Ministry of Health of the People's Republic of China and National Clinical Research Center for Respiratory Disease, Wuhan, China.
Xinyue MaDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Respiratory Diseases, National Ministry of Health of the People's Republic of China and National Clinical Research Center for Respiratory Disease, Wuhan, China.
Yunfei ZhuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Respiratory Diseases, National Ministry of Health of the People's Republic of China and National Clinical Research Center for Respiratory Disease, Wuhan, China.
Shuyun XuDepartment of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Respiratory Diseases, National Ministry of Health of the People's Republic of China and National Clinical Research Center for Respiratory Disease, Wuhan, China.
Liangkai ChenDepartment of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: clk@hust.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe bidirectional relationship between frailty and COPD is documented. However, longitudinal studies examining the combined effects of genetic predisposition and preserved ratio impaired spirometry (PRISm) on frailty in COPD development are lacking. RESEARCH QUESTION: What is the association between physical frailty and the incidence and mortality of COPD, and how do genetic predisposition and PRISm modify this association? STUDY DESIGN AND

methodsWe included 412,351 adults without COPD (mean age ± SD, 56.1 ± 8.1 years; 44.3% male) and 60,584 patients with COPD (mean age ± SD, 59.2 ± 7.4 years; 55.1% male) at baseline in the UK Biobank cohort. Frailty phenotypes were assessed using 5 components, including weight loss, exhaustion, low physical activity, slow gait speed, and low grip strength. Cox proportional hazards regression models were used to evaluate the association of genetic predisposition, PRISm, and frailty with COPD development. Life expectancy reductions due to frailty were estimated using life table methods in patients with COPD.

resultsDuring a median follow-up of 13.5 years, 10,695 incident COPD cases were recorded. In the multivariable-adjusted model, frailty and prefrailty were significantly associated with an increased risk of COPD (hazard ratio, 2.21; 95% CI, 2.06-2.37 for frailty; hazard ratio, 1.45; 95% CI, 1.39-1.51 for prefrailty). Significant interactions were observed between genetic predisposition and frailty (P for interaction = .0252), and between PRISm and frailty (P for interaction = .0027), in the development of COPD. Among patients with COPD at 45 years of age, frailty was associated with a reduction in life expectancy of 8.49 years for male individuals and 7.67 years for female individuals, whereas prefrailty was associated with reductions of 3.27 and 2.78 years, respectively, compared with their nonfrail counterparts.

interpretationThe results of this study indicate that frailty and prefrailty increase COPD risk and are linked to reduced life expectancy in patients with COPD, highlighting the need for early detection and management of frailty in COPD risk reduction and treatment strategies.

Indexed as

FrailtyLife ExpectancyPulmonary Disease, Chronic ObstructiveAgedCohort StudiesFemaleGenetic Predisposition to DiseaseHumansIncidenceMaleMiddle AgedRisk FactorsSpirometryUnited KingdomCOPDfrailtygenetic predispositionlife expectancypreserved ratio impaired spirometryUK Biobank

Identifiers

PMID40258513
PMCPMC12597428

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.