ArticleUltrasonics sonochemistry2025
Ultrasound-assisted extraction, purification, sulfation of Perilla leaves polysaccharide and hypoglycemic and hypolipidemic activities.
Article in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Bombyx mori-Hosted Cordyceps militaris Polysaccharides: Structural Characterization and Antibacterial Activity of Native and Sulfated Derivatives.Chemistry & biodiversity · 2026Article
- Sulfation Modification of Polysaccharides and Their Antidiabetic Activity.Journal of food science · 2026Review
- Water kefir grain polysaccharides: Ultrasonic-assisted extraction optimization, structural characterization, bioactivities, and application in goat yogurt.Ultrasonics sonochemistry · 2026Article
- Physicochemical Characterization and In Vitro Hypoglycemic Activity of a Low-Molecular-Weight Extracellular Polysaccharide From Deep-Sea Beauveria bassiana.Chemistry & biodiversity · 2026Article
- Research on the ultrasonic-assisted extraction, purification, structural characterization, and anti- glycolipid metabolic disorder (anti-GLMD) activity and mechanism of polysaccharide from Dryopteridis crassirhizomatis Rhizoma.Ultrasonics sonochemistry · 2026Article
- Method-Driven Physicochemical Profiling ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Comprehensive Review ofFoods (Basel, Switzerland) · 2025Review
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11 authors.
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Abstract
Perilla leaves are a common traditional medicinal and edible crop, in order to further explore its medicinal value, after determining the optimal ultrasound-assisted extraction conditions a neutral polysaccharide was extracted. Its structure was analyzed, and sulfation modification was carried out. After purification by different column chromatography, the optimal process for sulfation modification of PLP-2-1 was established, and sulfated modified PLP-2-1 (S-PLP-2-1) was successfully prepared. The potential structural framework and molecular weight of PLP-2-1 were determined by high performance liquid chromatography (HPLC), methylation analysis, and nuclear magnetic resonance (NMR) techniques, while sulfated modified S-PLP-2-1 maintained a high degree of structural similarity to PLP-2-1. Particle size analysis, Zeta potential measurement, infrared spectroscopy, and NMR analysis confirmed the presence of sulfate groups in S-PLP-2-1, while thermogravimetric and rheological analyses provided support for the development and utilization of these two polysaccharides. After determined the safe concentration range in vitro, the antioxidant and hypoglycemic activities of PLP-2-1 and S-PLP-2-1 were measured. Besides, the effects on the levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in oleic acid (OA) induced high-fat HepG2 cells of both polysaccharides were determined. The results indicated that the various biological activities of S-PLP-2-1 were significantly enhanced after sulfation modification. Therefore, PLP-2-1 and S-PLP-2-1 have the potential to be developed as drugs for anti-glycolipid metabolism disorders.
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