Evidence map›Paper›PMID 40258271›Full record

ArticleJournal of medical Internet research2025

Validation of an Adaptive Assessment of Executive Functions (Adaptive Cognitive Evaluation-Explorer): Longitudinal and Cross-Sectional Analyses of Cognitive Task Performance.

Kristine D O'Laughlin, Britte Haugan Cheng, Joshua J Volponi, John David A Lorentz, Sophia A Obregon, Jessica Wise Younger, Adam Gazzaley, Melina R Uncapher, Joaquin A Anguera

Abstract readValidation Study
In one paragraph

Article in Journal of medical Internet research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kristine D O'LaughlinNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0009-0001-4050-4321
Britte Haugan ChengNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0000-0001-5454-2903
Joshua J VolponiNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0000-0002-4986-0090
John David A LorentzNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0009-0000-1000-4767
Sophia A ObregonNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0009-0002-1181-4790
Jessica Wise YoungerNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0000-0002-4440-9081
Adam GazzaleyNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0000-0002-1232-9431
Melina R UncapherNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0000-0001-6732-4833
Joaquin A AngueraNeuroscape, Department of Neurology, University of California San Francisco, San Francisco, CA, United States.ORCID 0000-0002-7216-0674

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExecutive functions (EFs) predict positive life outcomes and educational attainment. Consequently, it is imperative that our measures of EF constructs are both reliable and valid, with advantages for research tools that offer efficiency and remote capabilities.

objectiveThe objective of this study was to evaluate reliability and validity evidence for a mobile, adaptive measure of EFs called Adaptive Cognitive Evaluation-Explorer (ACE-X).

methodsWe collected data from 2 cohorts of participants: a test-retest sample (N=246, age: mean 35.75, SD 11.74 y) to assess consistency of ACE-X task performance over repeated administrations and a validation sample involving child or adolescent (5436/6052, 89.82%; age: mean 12.78, SD 1.60 years) and adult participants (484/6052, 8%; age: mean 38.11, SD 14.96 years) to examine consistency of metrics, internal structures, and invariance of ACE-X task performance. A subset of participants (132/6052, 2.18%; age: mean 37.04, SD 13.23 years) also completed a similar set of cognitive tasks using the Inquisit platform to assess the concurrent validity of ACE-X.

resultsIntraclass correlation coefficients revealed most ACE-X tasks were moderately to very reliable across repeated assessments (intraclass correlation coefficient=0.45-0.79; P<.001). Moreover, in comparisons of internal structures of ACE-X task performance, model fit indices suggested that a network model based on partial correlations was the best fit to the data (χ

conclusionsThese findings suggest that ACE-X is a reliable and valid research tool for understanding EFs and their relations to outcome measures.

Indexed as

CognitionExecutive FunctionTask Performance and AnalysisAdolescentAdultChildCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedReproducibility of ResultsYoung Adultcognitive assessmentcomputerized assessmentexecutive functionsserious gamesvalidation

Identifiers

PMID40258271
PMCPMC12053272

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.