ArticleJCO oncology practice2026
Attributes and Health Care Resource Utilization of Patients on Enzalutamide or Abiraterone for Metastatic Castration-Resistant Cancer in England.
Article in JCO oncology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare demographics, clinical characteristics, health care resource utilization (HCRU), treatment duration, and overall survival (OS) with enzalutamide (ENZA) or abiraterone acetate (AA) in patients with metastatic castration-resistant prostate cancer (mCRPC) in England. MATERIALS AND
methodsThis retrospective study analyzed data from the Cancer Analysis System database on patients receiving ENZA or AA (January 2014-March 2020) for chemotherapy-naïve mCRPC (mCRPC was the only funded indication for ENZA/AA during study period). Baseline characteristics were assessed using standardized mean difference (SMD) (<0.1: balanced); differences were adjusted for using propensity score weighting (PSW). Cox proportional hazard models were used for OS and treatment duration. Number needed to treat was calculated from HCRU incidence rate ratios (IRRs).
resultsOverall, 8,485 patients were included (ENZA, 5,330; AA, 3,155). Diabetes mellitus was more prevalent in the ENZA group (SMD, 0.12) at treatment initiation. HCRU was comparable between groups before treatment initiation (SMD < 0.1), but HCRU IRR after treatment initiation favored ENZA. Compared with AA, ENZA was associated with significantly fewer inpatient stays, outpatient or accident and emergency (A&E) visits, and hospitalization days (
conclusionPatients with mCRPC on ENZA or AA had generally similar baseline characteristics apart from diabetes prevalence. ENZA was associated with longer OS and treatment duration, and lower HCRU after treatment initiation than AA.
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