Evidence map›Paper›PMID 40258132›Full record

ArticleACS chemical biology2025

Chemical Synthetic Lethality Screens Identify Selective Drug Combinations against

Ellysia N Overton, Yifan Zhang, Wabathi Ngecu, Mohammad R Seyedsayamdost

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ellysia N OvertonDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.
Yifan ZhangDepartment of Molecular Biology, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0001-6419-5108
Wabathi Ngecu
Mohammad R SeyedsayamdostDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.ORCID 0000-0003-2707-4854

Funding

From Genes to Molecules and Back: Expanding the Chemical Space of Microbial and Microbiome Natural ProductsR35GM152049 · NIGMS · PRINCETON UNIVERSITY · PI Mohammad R Seyedsayamdost · 2024 to 2026
$1.2M
Using Chemical Synthetic Lethality to Identify New Antimicrobial Targets in Gram-Negative Bacterial PathogensR21AI190827 · NIAID · PRINCETON UNIVERSITY · PI SEYEDSAYAMDOST, MOHAMMAD R · 2025 to 2025
$451k
NIAID NIH HHS R21 AI190827NIGMS NIH HHS R35 GM152049
6 · The paper itself

Abstract

The emergence of bacterial ESKAPE pathogens presents a formidable challenge to global health, necessitating the development of innovative strategies for antibiotic discovery. Here, we leverage chemical synthetic lethality to locate therapeutic combinations of small molecules against multidrug-resistant

Indexed as

Anti-Bacterial AgentsChlorhexidinePseudomonas aeruginosaCeftazidimeDrug Resistance, Multiple, BacterialHigh-Throughput Screening AssaysMicrobial Sensitivity TestsAnti-Bacterial AgentsCeftazidimeChlorhexidine

Identifiers

PMID40258132
PMCPMC13431984

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.