Evidence map›Paper›PMID 40257864›Full record

ArticleCell reports2025

MyD88-mediated signaling in intestinal fibroblasts regulates macrophage antimicrobial defense and prevents dysbiosis in the gut.

Marina Chulkina, Hanh Tran, Gabriela Uribe, Steven Bruce McAninch, Christina McAninch, Ashley Seideneck, Bing He, Matthew Lanza, Kamil Khanipov, Georgiy Golovko and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marina ChulkinaThe Pennsylvania State University, College of Medicine, Department of Medicine, Hershey, PA, USA.
Hanh TranThe Pennsylvania State University, Department of Biology, Huck Institute of the Life Sciences, University Park, PA, USA.
Gabriela UribeThe Pennsylvania State University, College of Medicine, Department of Medicine, Hershey, PA, USA.
Steven Bruce McAninchThe Pennsylvania State University, College of Medicine, Department of Medicine, Hershey, PA, USA.
Christina McAninchThe Pennsylvania State University, College of Medicine, Department of Medicine, Hershey, PA, USA.
Ashley SeideneckThe Pennsylvania State University, College of Medicine, Department of Medicine, Hershey, PA, USA.
Bing HeThe Pennsylvania State University, College of Medicine, Department of Medicine, Hershey, PA, USA.
Matthew LanzaThe Pennsylvania State University, College of Medicine, Department of Comparative Medicine, Hershey, PA, USA.
Kamil KhanipovThe University of Texas Medical Branch, Department of Pharmacology, Galveston, TX, USA.
Georgiy GolovkoThe University of Texas Medical Branch, Department of Pharmacology, Galveston, TX, USA.
Don W PowellThe University of Texas Medical Branch, Department of Internal Medicine, Galveston, TX, USA.
Emily R DavenportThe Pennsylvania State University, Department of Biology, Huck Institute of the Life Sciences, University Park, PA, USA.
Irina V PinchukThe Pennsylvania State University, College of Medicine, Department of Medicine, Hershey, PA, USA. Electronic address: ivp5097@psu.edu.

Funding

Regulatory role of CD90+ stromal cells in Th1/Th17 activity in Crohn's DiseaseR01DK103150 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PINCHUK, IRYNA V · 2014 to 2017
$1.4M
NIDDK NIH HHS R01 DK103150
6 · The paper itself

Abstract

Fibroblasts that reside in the gut mucosa are among the key regulators of innate immune cells, but their role in the regulation of the defense functions of macrophages remains unknown. MyD88 is suggested to shape fibroblast responses in the intestinal microenvironment. We found that mice lacking MyD88 in fibroblasts showed a decrease in the colonic antimicrobial defense, developing dysbiosis and aggravated dextran sulfate sodium (DSS)-induced colitis. These pathological changes were associated with the accumulation of Arginase 1

Indexed as

DysbiosisFibroblastsIntestinesMacrophagesMyeloid Differentiation Factor 88Signal TransductionAnimalsCathelicidinsChemokine CCL2ColitisDextran SulfateGastrointestinal MicrobiomeInterleukin-6Intestinal MucosaMaleMiceCathelicidinsChemokine CCL2Dextran SulfateInterleukin-6Myd88 protein, mouseMyeloid Differentiation Factor 88antimicrobial defenseCP: ImmunologydysbiosisfibroblastsgutmacrophagesMyD88

Identifiers

PMID40257864
PMCPMC12262590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.