Evidence map›Paper›PMID 40257857›Full record

ArticleEnvironmental health perspectives2025

Per- and Polyfluoroalkyl Substances in Eutopic Endometrium Tissue and Risk of Endometriosis: Findings from the Investigating Mixtures of Pollutants and Endometriosis in Tissue (IMPLANT) Study.

Joanna M Marroquin, Jenna R Krall, Karen C Schliep, Leslie V Farland, Vimalkumar Krishnamoorthi, Kurunthachalam Kannan, Anna Z Pollack

Abstract read
In one paragraph

Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joanna M MarroquinDepartment of Global and Community Health, College of Public Health, George Mason University, Fairfax, Virginia, USA.ORCID 0000-0002-5101-4977
Jenna R KrallDepartment of Global and Community Health, College of Public Health, George Mason University, Fairfax, Virginia, USA.
Karen C SchliepDepartment of Family and Preventive Medicine, University of Utah Health, Salt Lake City, Utah, USA.
Leslie V FarlandMel & Enid Zuckerman College of Public Health, The University of Arizona, Tucson, Arizona, USA.
Vimalkumar KrishnamoorthiWadsworth Center, New York State Department of Health, Albany, New York, USA.
Kurunthachalam KannanWadsworth Center, New York State Department of Health, Albany, New York, USA.
Anna Z PollackDepartment of Global and Community Health, College of Public Health, George Mason University, Fairfax, Virginia, USA.ORCID 0000-0002-4313-3298

Funding

SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
NICHD NIH HHS N01 DK063428NIEHS NIH HHS P30 ES006694
6 · The paper itself

Abstract

backgroundPer- and polyfluoroalkyl substances (PFAS) exposure is widespread and has been linked with gynecologic disease. To our knowledge, no study has measured PFAS in endometrial tissue.

methodsEutopic endometrial tissue specimens (

resultsParticipants were, on average,

conclusionPFAS were widely detected in eutopic endometrial tissue. There was no evidence that PFAS in endometrial tissue were associated with a higher risk of endometriosis diagnosis. However, PFOS, PFOSA, and PFHxS in the endometrial tissue were associated with risk of more severe stage of endometriosis. https://doi.org/10.1289/EHP15852.

Indexed as

EndometriosisEndometriumEnvironmental ExposureEnvironmental PollutantsFluorocarbonsAdultFemaleHumansMiddle AgedEnvironmental PollutantsFluorocarbons

Identifiers

PMID40257857
PMCPMC12129303

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.