ArticleSleep & breathing = Schlaf & Atmung2025
Autonomic dysfunction in obstructive sleep apnea syndrome: a pupillometric measurement study.
Article in Sleep & breathing = Schlaf & Atmung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Investigation of the effects of stress and quality of life in patients with obstructive sleep apnea syndrome.Sleep & breathing = Schlaf & Atmung · 2026Article
- Beyond the Eye: Sleep Fragmentation, Autonomic Dysregulation, and Mitochondrial Dysfunction as a Common Biological Soil for Meibomian Gland Pathology.Investigative ophthalmology & visual science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIt has been suggested that obstructive sleep apnea syndrome (OSAS) is associated with an imbalance in autonomic nervous system (ANS) tone. Pupil size is regarded as a reliable indicator of ANS function. Pupillometry, a straightforward and non-invasive technique, is used to measure both the size and dynamics of the pupil. This study aimed to investigate, through pupillometry, the hypothesis that individuals with OSAS exhibit dysregulation of the autonomic nervous system.
methodsIn this study, OSAS patients and a control group of healthy individuals were included. OSAS patients were divided into mild, moderate, and severe groups according to their apnea-hypopnea index (AHI) scores. In the study, mild sleep apnea is defined as an AHI between 5 and 14, moderate sleep apnea as an AHI between 15 and 29, and severe sleep apnea as an AHI of 30 or higher. Static and dynamic pupillometric measurements were performed in both groups under scotopic, mesopic, and photopic conditions using a digital infrared pupillometer to evaluate autonomic dysfunction.
resultsThe mean age of the study participants was 52.1 ± 10.4 years. A significant difference was observed between the groups in terms of mean AHI value (p < 0.001). There was no significant difference between the groups for static scotopic, mesopic, photopic pupil measurements (p > 0.05). However, significant differences were found for dynamic pupillary measurements (D1) (p = 0.023) and post-hoc analysis showed a significant difference between the control group and the severe OSAS group (p < 0.001). Correlation analysis revealed a significant correlation between age and AHI (r = 0.269, p = 0.003) and Moreover, a significant negative correlation was observed between AHI and D1 (r = -0.323, p < 0.001).
conclusionIn this study on pupillary measurements in OSAS patients, no significant difference was found in static pupillary responses in OSAS patients, whereas dynamic pupillary responses were found to be significantly impaired in severe OSAS. The significant impairment in severe OSAS suggests autonomic dysfunction due to hypoxia-induced neuronal damage. In conclusion, pupillometry may be a simple, noninvasive approach to detect ANS dysfunction in OSAS patients.
Indexed as
Identifiers
40257684What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.