Evidence map›Paper›PMID 40257662›Full record

ReviewNeuroscience bulletin2025

What Information do Systemic Pathological Changes Bring to the Diagnosis and Treatment of Alzheimer's Disease?

Jinyue Zhou, Xiaoli Sun, Keren Wang, Min Shen, Jingbo Yu, Qi Yao, Hang Hong, Chunlan Tang, Qinwen Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuroscience bulletin, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jinyue ZhouHealth Science Center, The First Affiliated Hospital, Ningbo University, Ningbo, 315010, China.
Xiaoli SunDepartment of Chemistry, Lishui University, Lishui, 32300, China.
Keren WangHealth Science Center, School of Public Health, Ningbo University, Ningbo, 315211, China.
Min ShenReference Laboratory, Medical System Biotechnology Co., Ltd, Ningbo, 315104, China.
Jingbo YuHealth Science Center, The First Affiliated Hospital, Ningbo University, Ningbo, 315010, China.
Qi YaoHealth Science Center, The First Affiliated Hospital, Ningbo University, Ningbo, 315010, China.
Hang HongHealth Science Center, School of Public Health, Ningbo University, Ningbo, 315211, China. honghang28@163.com.
Chunlan TangHealth Science Center, School of Public Health, Ningbo University, Ningbo, 315211, China. chunlant@163.com.ORCID http://orcid.org/0000-0001-5297-8965
Qinwen WangHealth Science Center, The First Affiliated Hospital, Ningbo University, Ningbo, 315010, China. wangqinwen@nbu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is regarded as a neurodegenerative disease, and it has been proposed that AD may be a systemic disease. Studies have reported associations between non-neurological diseases and AD. The correlations between AD pathology and systemic (non-neurological) pathological changes are intricate, and the mechanisms underlying these correlations and their causality are unclear. In this article, we review the association between AD and disorders of other systems. In addition, we summarize the possible mechanisms associated with AD and disorders of other systems, mainly from the perspective of AD pathology. Regarding the relationship between AD and systemic pathological changes, we aim to provide a new outlook on the early warning signs and treatment of AD, such as establishing a diagnostic and screening system based on more accessible peripheral samples.

Indexed as

Alzheimer DiseaseBrainHumansAlzheimer’s diseaseCentral nervous systemNon-neurological diseasesPeripheral system

Identifiers

PMID40257662
PMCPMC12229317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.